{"title":"Improved patch-clamp amplifier using software-based high-frequency boost","authors":"Jie Luo, Zhenhua Song, A. Qu","doi":"10.1109/INEC.2016.7589385","DOIUrl":null,"url":null,"abstract":"The large feedback resistors in the headstage of the patch-clamp amplifier lower the recording bandwidth to less than 100 Hz. A software-based high-frequency boost (SHB) was introduced in this paper. The algorithm consisted of two parts: 1) headstage dynamic characteristic identification using 4SID method; 2) bandwidth compensation using zero-pole matching. Both time and frequency domain analysis demonstrated SHB should be a satisfied alternative to the traditional high-frequency boost circuit.","PeriodicalId":416565,"journal":{"name":"2016 IEEE International Nanoelectronics Conference (INEC)","volume":"309 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2016 IEEE International Nanoelectronics Conference (INEC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/INEC.2016.7589385","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The large feedback resistors in the headstage of the patch-clamp amplifier lower the recording bandwidth to less than 100 Hz. A software-based high-frequency boost (SHB) was introduced in this paper. The algorithm consisted of two parts: 1) headstage dynamic characteristic identification using 4SID method; 2) bandwidth compensation using zero-pole matching. Both time and frequency domain analysis demonstrated SHB should be a satisfied alternative to the traditional high-frequency boost circuit.
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