Quantitative relations between acoustic inertial cavitation and gene transfection rate/cell viability

Chun-Yen Lai, Chia-Hsuan Wu, C. Chen, Pai-Chi Li
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引用次数: 2

Abstract

Ultrasound has been utilized to assist gene transfection. In combination with ultrasound, microbubble-based contrast agents have also been used to enhance the transfection efficiency by inducing acoustic inertial cavitation. However, the relations between inertial cavitation and gene transfection rate/cell viability are still unknown. It is the primary purpose of this study to examine the relations experimentally and quantitatively. A commercial contrast agent Levovist ® was used, and
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声惯性空化与基因转染率/细胞存活率的定量关系
超声已被用于辅助基因转染。微泡造影剂也被用于与超声结合,通过诱导声惯性空化来提高转染效率。然而,惯性空化与基因转染率/细胞存活率之间的关系尚不清楚。本研究的主要目的是通过实验和定量的方法来检验它们之间的关系。使用商用造影剂Levovist®
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Creating antibubbles with ultrasound Nonlinear imaging of targeted microbubbles with intravascular ultrasound Improved spatiotemporal voxel space interpolation for 3D echocardiography with irregular sampling and multibeat fusion A novel back scattering ultrasound transducer for non-destructive material evaluation and defect inspection Quantitative relations between acoustic inertial cavitation and gene transfection rate/cell viability
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