Invitro cytotoxic study of aloe vera whole leaf extract on PBMC and breast cancer cell line

Abstract

Many anticancer drugs currently used have an origin from natural sources. It is reported that in between 1981 and 2006, 47.1% of the 155 clinically approved anti-cancer drugs, were unmodified natural products or their semi-synthetic derivatives or even synthesized molecules based on natural models [4]. Aloe vera is one of the oldest known medicinal plants. Studies show that the Aloe vera leaf extract is effective on various cancers like colon cancer, neuroectodermal cancer [1,2] but there is very less sufficient data on breast cancer. Therefore, we evaluate the effect of Aloe leaf extract on breast cancer cell. Phytochemical test of the extract confirms presence of Alkaloids, Phenolic compounds. The antioxidant activity of such phytochemicals are very useful to inhibit cancer [3,4,19]. MTT Assay was performed on PBMC and MCF-7 cell line with aloe vera extract. Experimental data suggest that Aloe vera whole leaf extract significantly increases the cytotoxic effect on human breast cancer cell compare to normal cell (PBMC). Our study evaluated specific cytotoxic effect of Aloe vera extract on human breast cancer cell and further study is required to develop Aloe vera extract base drug for the treatment of breast cancer.