The Anticancer Activity of Chalcone Compounds against Human Prostate Carcinoma Cell And Human Colon Colorectal Adenocarcinoma

Abstract

Cancer is the second most common cause of death in our country and also worldwide. In the cancer treatment are used many methods such as surgery, chemotherapy, radiotherapy and hormone therapy. Despite these methods, a decrease is not observed in cancer cases and in the mortality. In addition, cancer drugs cause serious side effects. Therefore, there is a need for new anticancer drugs. Chalcones have broad anticancer activity against various cancer cells. In this study, the anticancer activities of the chalcone compounds were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed using the BrdU ELISA method. 5 - Fluorouracil (5 - FU) was used as the positive control. Compound 1-7 ( except Compound 3 ) were determined having higher anticancer activity than 5 - FU against PC3 cancer cells. IC 50 values of the compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM ; 4.40±0.03 µM ; 5.86±0.02 µM ; 4.36±0.03 µM; 1.76±0.02 µM ; 1.78±0.03 µM ; 2.31±0.03 µM , respectively.