In this study, Cu-polylactic acid (PLA) composite filaments were produced with an extruder and three-dimensional (3D) Cu/PLA electrodes were 3D printed with Fused Deposition Modelling (FDM) method. To improve the electrochemical performance of the 3D-Cu/PLA electrode, a novel electrochemical activation method, which differentiates from complex activation methods in the literature, was applied in 1 M KOH solution without using any solvent. Field emission scanning electron microscopy (FE-SEM), Energy-Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FT-IR), and RAMAN techniques were used to characterize the 3D-Cu/PLA electrode before and after activation. The results showed that Cu particles were released after the degradation of PLA after activation. In addition, the thermal stability of the 3D electrode was demonstrated by the TGA technique. The performance of the 3D Cu/PLA electrode before and after activation in the hydrogen evolution reaction (HER) in 1M solution was measured using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and cathodic polarization curves methods. The EIS results showed that the charge transfer resistance values of the 3D-Cu/PLA electrode in 1 M KOH decreased significantly after activation. Post-activation hydrogen content measurements of the 3D-Cu/PLA electrode after electrolysis at different potentials and energy efficiency tests at different current densities were also carried out. The results indicate that the electrocatalytic properties of 3D-Cu electrodes were improved for HER through the activation process.
本研究利用挤压机生产了铜-聚乳酸（PLA）复合丝，并采用熔融沉积建模（FDM）方法三维打印了三维（3D）铜/聚乳酸电极。为了提高三维铜/聚乳酸电极的电化学性能，在 1 M KOH 溶液中采用了一种有别于文献中复杂活化方法的新型电化学活化方法，且不使用任何溶剂。采用场发射扫描电子显微镜（FE-SEM）、能量色散 X 射线光谱（EDX）、傅立叶变换红外光谱（FT-IR）和 RAMAN 技术对活化前后的 3D-Cu/PLA 电极进行了表征。结果表明，活化后的聚乳酸降解后会释放出铜颗粒。此外，TGA 技术还证明了三维电极的热稳定性。使用循环伏安法（CV）、电化学阻抗谱法（EIS）和阴极极化曲线法测量了三维铜/聚乳酸电极在 1M 溶液中氢进化反应（HER）中活化前后的性能。EIS 结果表明，3D-Cu/PLA 电极在 1 M KOH 中的电荷转移电阻值在活化后显著下降。此外，还测量了三维铜/聚乳酸电极在不同电位下电解后的活化氢含量，以及在不同电流密度下的能效测试。结果表明，通过活化过程，三维铜电极对 HER 的电催化性能得到了改善。
{"title":"Production and New Green Activation of Conductive 3D-Printed Cu/PLA Electrode: Its Performance in Hydrogen Evolution Reactions in Alkaline Media","authors":"Halil Eki̇ci̇, Sevgi Ateş, Evrim Baran Aydın","doi":"10.32571/ijct.1375421","DOIUrl":"https://doi.org/10.32571/ijct.1375421","url":null,"abstract":"In this study, Cu-polylactic acid (PLA) composite filaments were produced with an extruder and three-dimensional (3D) Cu/PLA electrodes were 3D printed with Fused Deposition Modelling (FDM) method. To improve the electrochemical performance of the 3D-Cu/PLA electrode, a novel electrochemical activation method, which differentiates from complex activation methods in the literature, was applied in 1 M KOH solution without using any solvent. Field emission scanning electron microscopy (FE-SEM), Energy-Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FT-IR), and RAMAN techniques were used to characterize the 3D-Cu/PLA electrode before and after activation. The results showed that Cu particles were released after the degradation of PLA after activation. In addition, the thermal stability of the 3D electrode was demonstrated by the TGA technique. The performance of the 3D Cu/PLA electrode before and after activation in the hydrogen evolution reaction (HER) in 1M solution was measured using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and cathodic polarization curves methods. The EIS results showed that the charge transfer resistance values of the 3D-Cu/PLA electrode in 1 M KOH decreased significantly after activation. Post-activation hydrogen content measurements of the 3D-Cu/PLA electrode after electrolysis at different potentials and energy efficiency tests at different current densities were also carried out. The results indicate that the electrocatalytic properties of 3D-Cu electrodes were improved for HER through the activation process.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"123 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunus Başar, Semiha Yenigün, F. Gül, T. Ozen, Ibrahim Demirtas, M. Alma, S. Temel
Dünyanın kurak ve yarı kurak bölgelerinde doğal olarak yetişen Atriplex nitens Schkuhr (ANS), kuraklığa ve tuzlu ortamlara karşı oldukça dayanıklı olup gıda ve hayvan yemi olarak kullanılmaktadır. Bu çalışmada ilk olarak ANS'nin elde edilen metanol ham ekstraktı üzerinde fitokimyasal analiz ile antioksidan ve üreaz inhibisyon aktiviteleri gerçekleştirilmiştir. LC-MS/MS sonuçlarına göre kateşin ve izokersitrin ana bileşikler olarak tespit edildi. Ekstraktın GC-MS/MS analizinde oleik asit metil ester (%31.71), palmitik asit metil ester (%25.87), linoleik asit metil ester (19.61) ve nonakozan (%6.81) tespit edildi. ANS ekstraktının posfomolibden indrgenme, DPPH֗ giderici ve üreaz inhibisyon aktiviteleri sırasıyla 67.27±23.83, 7.85±0.44 ve 6.58±0.48 µg/mL düzeyinde etkili bulunmuştur. Bu araştırmada öncelikle ANS ekstraktının biyolojik aktivitesi ve kimyasal bileşimi incelenmiştir. Bu bitkinin en bol bulunan iki bileşeni üzerinde moleküler yerleştirme ve ADMET tahmini gerçekleştirildi. İzokersitrin üreazının (MolDock skoru -121.42, bağlanma afinitesi -8.60 ve bağlanma sabiti 0.62 µM) üreaz ile etkileşiminin üreaz ile etkileşiminin daha yüksek olduğu belirlendi. Bu iki bileşenin toksisite açısından ihmal edilebilir bir potansiyeli vardır. Boiled Egg grafiği kateşin için önemli bir GIa'ya işaret etmektedir. Ancak izokersitrin BBB veya GLa geçirgenliği gösterdi. Moleküler etkileşimde isokersitrin en iyisidir, ADMET'te ise kateşin en iyisidir. Ana bileşen izokersitrinin mide hastalıkların karşı etkili olabileceği belirlendi ve BBB ile GLa sistemlerinde gözlemlenmemesi desteklendi.
{"title":"Phytochemical profiling, molecular docking and ADMET prediction of crude extract of Atriplex nitens Schkuhr for the screening of antioxidant and urease inhibitory","authors":"Yunus Başar, Semiha Yenigün, F. Gül, T. Ozen, Ibrahim Demirtas, M. Alma, S. Temel","doi":"10.32571/ijct.1389719","DOIUrl":"https://doi.org/10.32571/ijct.1389719","url":null,"abstract":"Dünyanın kurak ve yarı kurak bölgelerinde doğal olarak yetişen Atriplex nitens Schkuhr (ANS), kuraklığa ve tuzlu ortamlara karşı oldukça dayanıklı olup gıda ve hayvan yemi olarak kullanılmaktadır. Bu çalışmada ilk olarak ANS'nin elde edilen metanol ham ekstraktı üzerinde fitokimyasal analiz ile antioksidan ve üreaz inhibisyon aktiviteleri gerçekleştirilmiştir. LC-MS/MS sonuçlarına göre kateşin ve izokersitrin ana bileşikler olarak tespit edildi. Ekstraktın GC-MS/MS analizinde oleik asit metil ester (%31.71), palmitik asit metil ester (%25.87), linoleik asit metil ester (19.61) ve nonakozan (%6.81) tespit edildi. ANS ekstraktının posfomolibden indrgenme, DPPH֗ giderici ve üreaz inhibisyon aktiviteleri sırasıyla 67.27±23.83, 7.85±0.44 ve 6.58±0.48 µg/mL düzeyinde etkili bulunmuştur. Bu araştırmada öncelikle ANS ekstraktının biyolojik aktivitesi ve kimyasal bileşimi incelenmiştir. Bu bitkinin en bol bulunan iki bileşeni üzerinde moleküler yerleştirme ve ADMET tahmini gerçekleştirildi. İzokersitrin üreazının (MolDock skoru -121.42, bağlanma afinitesi -8.60 ve bağlanma sabiti 0.62 µM) üreaz ile etkileşiminin üreaz ile etkileşiminin daha yüksek olduğu belirlendi. Bu iki bileşenin toksisite açısından ihmal edilebilir bir potansiyeli vardır. Boiled Egg grafiği kateşin için önemli bir GIa'ya işaret etmektedir. Ancak izokersitrin BBB veya GLa geçirgenliği gösterdi. Moleküler etkileşimde isokersitrin en iyisidir, ADMET'te ise kateşin en iyisidir. Ana bileşen izokersitrinin mide hastalıkların karşı etkili olabileceği belirlendi ve BBB ile GLa sistemlerinde gözlemlenmemesi desteklendi.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"104 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139133784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunus Başar, Semiha Yenigün, L. Behçet, T. Ozen, Ibrahim Demirtas
1,5,9-epideoksiloganik asit (ELA), endemik Nepeta aristata ham metanol-kloroform ham ekstraktının metanol fraksiyonundan kromatografik yöntemlerle (preparatif-HPLC, silika ve sefadeks kolon) izole edildi. ELA'nın yapısı 1H NMR ve 13C NMR spektrometrisi ile belirlendi. Ayrıca molekülün kütlesi kütle spektrometresi ile doğrulandı. ELA'nın antioksidan ve antibakteriyel aktiviteleri araştırıldı ve standartlarla karşılaştırıldı. ELA, K. pneumoniae (11.50 mm), S. aureus'a (10.00 mm) karşı inhibisyon bölgesi ile en iyi antibakteriyel aktiviteyi ve ayrıca E. faecalis'e (8 µg/mL) karşı etkili minimum inhibisyon konsantrasyon değerini sergiledi. ELA'nın antioksidan aktiviteleri fosfomolibdenyum indirgeme, indirgeme gücü, metal şelatlama, H2O2, serbest radikal (DPPH·), ABTS˙⁺ ve O2˙ˉ giderme aktiviteleriyle değerlendirildi. ELA'nın fosfomolibdenyum, O2˙ˉ ve H2O2 giderme aktiviteleri sırasıyla 136.02±3.99, 3.54±0.26 ve 9.67±1.26 µg/mL düzeyinde etkili bulunmuştur. Sonuç olarak ELA molekülünün etkili antioksidan ve antimikrobiyal aktivite değerleri gelecekte farmakolojide kullanılabilecek bir kaynak olabilir.
{"title":"Antibacterial and Antioxidant Molecule Isolated from Nepeta aristata Boiss Et Kotschy Ex Boiss plant: 1,5,9-Epideoxyloganic Acid","authors":"Yunus Başar, Semiha Yenigün, L. Behçet, T. Ozen, Ibrahim Demirtas","doi":"10.32571/ijct.1381998","DOIUrl":"https://doi.org/10.32571/ijct.1381998","url":null,"abstract":"1,5,9-epideoksiloganik asit (ELA), endemik Nepeta aristata ham metanol-kloroform ham ekstraktının metanol fraksiyonundan kromatografik yöntemlerle (preparatif-HPLC, silika ve sefadeks kolon) izole edildi. ELA'nın yapısı 1H NMR ve 13C NMR spektrometrisi ile belirlendi. Ayrıca molekülün kütlesi kütle spektrometresi ile doğrulandı. ELA'nın antioksidan ve antibakteriyel aktiviteleri araştırıldı ve standartlarla karşılaştırıldı. ELA, K. pneumoniae (11.50 mm), S. aureus'a (10.00 mm) karşı inhibisyon bölgesi ile en iyi antibakteriyel aktiviteyi ve ayrıca E. faecalis'e (8 µg/mL) karşı etkili minimum inhibisyon konsantrasyon değerini sergiledi. ELA'nın antioksidan aktiviteleri fosfomolibdenyum indirgeme, indirgeme gücü, metal şelatlama, H2O2, serbest radikal (DPPH·), ABTS˙⁺ ve O2˙ˉ giderme aktiviteleriyle değerlendirildi. ELA'nın fosfomolibdenyum, O2˙ˉ ve H2O2 giderme aktiviteleri sırasıyla 136.02±3.99, 3.54±0.26 ve 9.67±1.26 µg/mL düzeyinde etkili bulunmuştur. Sonuç olarak ELA molekülünün etkili antioksidan ve antimikrobiyal aktivite değerleri gelecekte farmakolojide kullanılabilecek bir kaynak olabilir.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"29 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139147712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim Demirtas, T. Ozen, Sarmad Marah, Dogukan Mutlu, Ş. Arslan, F. Gül
Özet Bu günlerde, zarar verme potansiyelinin düşük olması ve düşük maliyetle geliştirilebilmesi nedeniyle yeni bitki tıbbi kaynaklarına olan ihtiyaç arttmaktadır. Çam bitkisinin mükemmel doğal ve ekonomik katkıları vardır. Ayrıca çam ekstraktları çok sayıda biyoaktif kimyasal bileşiklere sahiptir. Bu çalışmada Pinus sylvestris kabuğu (PSB: Sarı Çam) ve Pinus nigra kabuğu (PNB: Kara Çam) ekstraktlarının kimyasal bileşimini ve biyoaktivitesini belirlemeyi ve ayrıca ticari bir ürünü karşılaştırmayı amaçladık. PSB ekstraktı kolon kromatografisi ile fraksiyonlara ayrıldı. PSB ekstraktının PSB-FR-2 fraksiyonu, 157.62±1.06 mg GAE g-1 ekstraktı gibi yüksek bir fenolik içeriğe sahipti. PNB ve PSB ekstraktlarının -amilaz ve -glukosidaza karşı inhibitör aktiviteleri, akarbozla karşılaştırıldığında akarbozun iki katı aktivite göstermiştir. Üstelik qPCR testi, PSB ekstraktının, 50 µg mL-1 gibi en düşük konsantrasyonda bile akciğer hücrelerinde ACE2 geninin ekspresyonunu azaltabildiğini gösterdi. MIC testi, ekstraktların potansiyel olarak antibakteriyel etkilere sahip olabileceğini gösterdi. Sonuçlarımız, PNB, PSB ekstraktları ve PBS fraksiyonlarının yüksek fenolik ve flavonoid metabolit içeriğinin yanı sıra çeşitli biyoaktiviteye sahip olduğunu ortaya koymaktadır. Dolayısıyla, ileriye yönelik çalışmalar için umut verici bir doğal tıbbi ürün modeli olabilir.
{"title":"Functional Food Components and Activities of Pinus nigra and Pinus sylvestris Barks as Food Supplements","authors":"Ibrahim Demirtas, T. Ozen, Sarmad Marah, Dogukan Mutlu, Ş. Arslan, F. Gül","doi":"10.32571/ijct.1360577","DOIUrl":"https://doi.org/10.32571/ijct.1360577","url":null,"abstract":"Özet Bu günlerde, zarar verme potansiyelinin düşük olması ve düşük maliyetle geliştirilebilmesi nedeniyle yeni bitki tıbbi kaynaklarına olan ihtiyaç arttmaktadır. Çam bitkisinin mükemmel doğal ve ekonomik katkıları vardır. Ayrıca çam ekstraktları çok sayıda biyoaktif kimyasal bileşiklere sahiptir. Bu çalışmada Pinus sylvestris kabuğu (PSB: Sarı Çam) ve Pinus nigra kabuğu (PNB: Kara Çam) ekstraktlarının kimyasal bileşimini ve biyoaktivitesini belirlemeyi ve ayrıca ticari bir ürünü karşılaştırmayı amaçladık. PSB ekstraktı kolon kromatografisi ile fraksiyonlara ayrıldı. PSB ekstraktının PSB-FR-2 fraksiyonu, 157.62±1.06 mg GAE g-1 ekstraktı gibi yüksek bir fenolik içeriğe sahipti. PNB ve PSB ekstraktlarının -amilaz ve -glukosidaza karşı inhibitör aktiviteleri, akarbozla karşılaştırıldığında akarbozun iki katı aktivite göstermiştir. Üstelik qPCR testi, PSB ekstraktının, 50 µg mL-1 gibi en düşük konsantrasyonda bile akciğer hücrelerinde ACE2 geninin ekspresyonunu azaltabildiğini gösterdi. MIC testi, ekstraktların potansiyel olarak antibakteriyel etkilere sahip olabileceğini gösterdi. Sonuçlarımız, PNB, PSB ekstraktları ve PBS fraksiyonlarının yüksek fenolik ve flavonoid metabolit içeriğinin yanı sıra çeşitli biyoaktiviteye sahip olduğunu ortaya koymaktadır. Dolayısıyla, ileriye yönelik çalışmalar için umut verici bir doğal tıbbi ürün modeli olabilir.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"26 S70","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139146838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of chalcone derivatives were synthesized as a result of the Claisen-Schmidt condensation of different aldehydes with CH3 groups with 4-piperazineacetophenone. Anticholinesterase (AChE and BChE) inhibitory activity and antidiabetes (α-amylase and α-glucosidaze) inhibitory activities of the synthesized compounds were examined. While compound 1 is the most active molecule in AChE (16.29±0.44 IC50 µM), BChE (10.19±0.04 IC50 µM) and α-amylase (105.51±0.24 IC50 µM) inhibitor activities; Compound 5 was found to be the most active molecule in α-glucosidase inhibitor activity. In silico and molecular docking studies of all molecules were performed. According to molecular docking results, all molecules were found to be more active than the reference compounds.
{"title":"Synthesis, Biological Activity Studies And Molecular Modeling Studies Of Chalcone Compounds With Methyl Group","authors":"Bedriye Seda Kurşun Aktar","doi":"10.32571/ijct.1389889","DOIUrl":"https://doi.org/10.32571/ijct.1389889","url":null,"abstract":"A series of chalcone derivatives were synthesized as a result of the Claisen-Schmidt condensation of different aldehydes with CH3 groups with 4-piperazineacetophenone. Anticholinesterase (AChE and BChE) inhibitory activity and antidiabetes (α-amylase and α-glucosidaze) inhibitory activities of the synthesized compounds were examined. While compound 1 is the most active molecule in AChE (16.29±0.44 IC50 µM), BChE (10.19±0.04 IC50 µM) and α-amylase (105.51±0.24 IC50 µM) inhibitor activities; Compound 5 was found to be the most active molecule in α-glucosidase inhibitor activity. In silico and molecular docking studies of all molecules were performed. According to molecular docking results, all molecules were found to be more active than the reference compounds.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139147534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilyas Yildiz, R. Erenler, M. Alma, Ö. Isildak, Tarık Aral
(1S, 2S, N1, N2) -N1, N2 bis ((2-metil-1H-indol-3-il) metilen) sikloheksan-1,2 -diamin (iyonofor) bileşik bazlı demir (III) iyonuna seçici yeni bir katı hal kontak potansiyometrik membran elektrodu geliştirildi. Öncelikle geliştirilen elektrotun minimum membran bileşimi belirlendi. Ayrıca elektrotun seçicilik, tespit limiti, pH aralığı, tepki süresi, konsantrasyon aralığı ve potansiyel kararlılık gibi potansiyometrik performans özellikleri de araştırıldı. Elde edilen sonuçlar, elektrotun 43.00 ± 5 mV/decade Nernstian temki değerine ve geniş doğrusal konsantrasyon aralığında (1.0×10−6-1,0×10-2 M) çok düşük tayın sınırına (6.5×10-6 M) sahip olduğunu gösterdi. Elektrotun potansiyometrik pH tepkisi 2-11 gibi geniş bir aralıkta olup çözeltilere verdiği süre
{"title":"A new PVC Membrane Potentiometric Electrode Based on (1S, 2S, N1, N2) -N1, N2 bis ((2-methyl-1H-indol-3-yl) methylene) cyclohexane-1,2 -diamine for Detection of Fe (III) Ions","authors":"Ilyas Yildiz, R. Erenler, M. Alma, Ö. Isildak, Tarık Aral","doi":"10.32571/ijct.1374226","DOIUrl":"https://doi.org/10.32571/ijct.1374226","url":null,"abstract":"(1S, 2S, N1, N2) -N1, N2 bis ((2-metil-1H-indol-3-il) metilen) sikloheksan-1,2 -diamin (iyonofor) bileşik bazlı demir (III) iyonuna seçici yeni bir katı hal kontak potansiyometrik membran elektrodu geliştirildi. Öncelikle geliştirilen elektrotun minimum membran bileşimi belirlendi. Ayrıca elektrotun seçicilik, tespit limiti, pH aralığı, tepki süresi, konsantrasyon aralığı ve potansiyel kararlılık gibi potansiyometrik performans özellikleri de araştırıldı. Elde edilen sonuçlar, elektrotun 43.00 ± 5 mV/decade Nernstian temki değerine ve geniş doğrusal konsantrasyon aralığında (1.0×10−6-1,0×10-2 M) çok düşük tayın sınırına (6.5×10-6 M) sahip olduğunu gösterdi. Elektrotun potansiyometrik pH tepkisi 2-11 gibi geniş bir aralıkta olup çözeltilere verdiği süre","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139144337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanotechnology is the most well-known disciplines of science due to its wide range of applications. Nanoparticles have been used commonly for agriculture, electronic, medicine, medicinal material, and sensory. In this study, Prunus laurocerasus L. fruits were heated in distilled water for 2 hours at 40°C. After filtration, the treatment of silver nitrate (1.0 mM) with plant solution yielded silver nanoparticles (AgNPsμ@pl). Advanced spectroscopic techniques elucidated the synthesized AgNPs@pl. The functional moieties of secondary metabolites responsible for capping, reducing and stabilizing agents were determined by Fourier transform infrared spectroscopy (FTIR). The surface plasmon resonance at 468 nm was presented by UV-Vis spectroscopy. Transmission electron microscopy (TEM) displayed the particles as spherical in the size of 15 nm. The structure and particle size were also calculated by X-ray diffraction (XRD) spectroscopy and AgNPsμ@pl were found as cubic structure with the particle size of 17 nm. The zeta potential confirmed the stability of nanostructures. The high negative zeta potential value (-16.5 mV) displayed the dispersion of the nanostructure with stability.
{"title":"Green synthesis and characterisation of silver nanoparticles using Prunus laurocerasus L. fruits","authors":"Tunay Karan, R. Erenler","doi":"10.32571/ijct.1341868","DOIUrl":"https://doi.org/10.32571/ijct.1341868","url":null,"abstract":"Nanotechnology is the most well-known disciplines of science due to its wide range of applications. Nanoparticles have been used commonly for agriculture, electronic, medicine, medicinal material, and sensory. In this study, Prunus laurocerasus L. fruits were heated in distilled water for 2 hours at 40°C. After filtration, the treatment of silver nitrate (1.0 mM) with plant solution yielded silver nanoparticles (AgNPsμ@pl). Advanced spectroscopic techniques elucidated the synthesized AgNPs@pl. The functional moieties of secondary metabolites responsible for capping, reducing and stabilizing agents were determined by Fourier transform infrared spectroscopy (FTIR). The surface plasmon resonance at 468 nm was presented by UV-Vis spectroscopy. Transmission electron microscopy (TEM) displayed the particles as spherical in the size of 15 nm. The structure and particle size were also calculated by X-ray diffraction (XRD) spectroscopy and AgNPsμ@pl were found as cubic structure with the particle size of 17 nm. The zeta potential confirmed the stability of nanostructures. The high negative zeta potential value (-16.5 mV) displayed the dispersion of the nanostructure with stability.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"244 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139170871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Compounds including a triazole skeleton and an imine functional group in their structures have a broad range of applications in drug discovery due to their biological activities. Herein, the novel Schiff bases bearing 1-(o-tolyl)-4-(phenoxymethyl)-(1H)1,2,3-triazole derivatives were synthesized and the structures of newly synthesized compounds were characterized by FTIR, 1D and 2D NMR and mass spectral data. Computational analysis was performed to optimize the structures of the synthesized compounds with density functional theory (DFT) using the B3LYP method at the 6-311++G(d,p) basis set in the gas phase. The binding affinity values obtained from docking studies of Schiff bases (2a-2d) on sterol 14α-demethylase (CYP51) indicate that compounds 2c and 2d have a higher potential as CYP51 inhibitors compared to compounds 2a and 2b. It was found that the incorporation of a benzene ring into the structure significantly increased the binding affinity from -9.0 to -11.5 kcal mol-1.
{"title":"The synthesis, characterization and molecular docking studies of novel Schiff bases bearing 1-(o-tolyl)-4-(phenoxymethyl)-(1H)1,2,3-triazole derivatives","authors":"Selbi Keskin, Derya Vural","doi":"10.32571/ijct.1386211","DOIUrl":"https://doi.org/10.32571/ijct.1386211","url":null,"abstract":"Compounds including a triazole skeleton and an imine functional group in their structures have a broad range of applications in drug discovery due to their biological activities. Herein, the novel Schiff bases bearing 1-(o-tolyl)-4-(phenoxymethyl)-(1H)1,2,3-triazole derivatives were synthesized and the structures of newly synthesized compounds were characterized by FTIR, 1D and 2D NMR and mass spectral data. Computational analysis was performed to optimize the structures of the synthesized compounds with density functional theory (DFT) using the B3LYP method at the 6-311++G(d,p) basis set in the gas phase. The binding affinity values obtained from docking studies of Schiff bases (2a-2d) on sterol 14α-demethylase (CYP51) indicate that compounds 2c and 2d have a higher potential as CYP51 inhibitors compared to compounds 2a and 2b. It was found that the incorporation of a benzene ring into the structure significantly increased the binding affinity from -9.0 to -11.5 kcal mol-1.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bee pollen plays a significant role in bee nutrition, bee population sustainability, pollination processes, and its health and nutritional benefits for humans. It contains protein, vitamins, minerals, and antioxidants, offering valuable nutritional properties. The total phenolic content (TPC) is an important parameter in determining the nutritional and health value of pollen. The presence of high levels of phenolic compounds in pollen enhances their health benefits and can provide protective effects against diseases by combating oxidative stress. In the study, ultrasonic extraction conditions for pollen were optimized using the Response Surface Method to maximize TPC. The experimental study was designed according to Box-Behnken design: 30–70% ethanol ratio, 5–15 min of extraction time, and 10–20% ultrasonic amplitude modulation (AM). The TPC of the obtained extracts were determined using the Folin-Ciocalteu procedure. The optimal extraction conditions were predicted as 60.012% ethanol ratio, 11.054 min, and 19.160% AM for reaching 9.572 mg/GAE g extract.
{"title":"Optimization of ultrasonic extraction conditions using response surface methodology: total phenolic content of bee pollen","authors":"Ayşenur Gürgen, Z. Can, Y. Kara, Hüseyin Şahi̇n","doi":"10.32571/ijct.1340424","DOIUrl":"https://doi.org/10.32571/ijct.1340424","url":null,"abstract":"Bee pollen plays a significant role in bee nutrition, bee population sustainability, pollination processes, and its health and nutritional benefits for humans. It contains protein, vitamins, minerals, and antioxidants, offering valuable nutritional properties. The total phenolic content (TPC) is an important parameter in determining the nutritional and health value of pollen. The presence of high levels of phenolic compounds in pollen enhances their health benefits and can provide protective effects against diseases by combating oxidative stress. In the study, ultrasonic extraction conditions for pollen were optimized using the Response Surface Method to maximize TPC. The experimental study was designed according to Box-Behnken design: 30–70% ethanol ratio, 5–15 min of extraction time, and 10–20% ultrasonic amplitude modulation (AM). The TPC of the obtained extracts were determined using the Folin-Ciocalteu procedure. The optimal extraction conditions were predicted as 60.012% ethanol ratio, 11.054 min, and 19.160% AM for reaching 9.572 mg/GAE g extract.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139168951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the presence of a thermal bridge in the building, some of the required energy becomes inactive in order to provide thermal comfort in the building. This situation negatively affects the energy efficiency of the building. The energy sources used throughout the world for air conditioning are fossil fuels with limited reserves. In terms of sustainability, transferring fossil fuels to future generations is an important issue. In addition, carbon dioxide, which is formed by the use of fossil fuels in energy supply, is one of the basic parameters monitored in global warming. Carbon dioxide, which is a monitoring parameter on climate change, is a parameter that is controlled during the fight against global warming. Various studies are carried out and policies are developed to reduce carbon dioxide emissions around the world. In the construction sector, which is among the areas where energy is used in large amounts throughout the world, a large part of the energy is consumed for air conditioning. At this stage, thermal bridges and insulation application in the building is a very important issue. In this study, the concept of thermal bridge has been evaluated on the basis of energy losses and environmental effects in the building.
{"title":"Yapıda Isı Köprüsü, Enerji Kayıpları ve Çevresel Etkileri","authors":"Hasan Kıvanç Yeşi̇ltaş","doi":"10.32571/ijct.1208607","DOIUrl":"https://doi.org/10.32571/ijct.1208607","url":null,"abstract":"In the presence of a thermal bridge in the building, some of the required energy becomes inactive in order to provide thermal comfort in the building. This situation negatively affects the energy efficiency of the building. The energy sources used throughout the world for air conditioning are fossil fuels with limited reserves. In terms of sustainability, transferring fossil fuels to future generations is an important issue. In addition, carbon dioxide, which is formed by the use of fossil fuels in energy supply, is one of the basic parameters monitored in global warming. Carbon dioxide, which is a monitoring parameter on climate change, is a parameter that is controlled during the fight against global warming. Various studies are carried out and policies are developed to reduce carbon dioxide emissions around the world. In the construction sector, which is among the areas where energy is used in large amounts throughout the world, a large part of the energy is consumed for air conditioning. At this stage, thermal bridges and insulation application in the building is a very important issue. In this study, the concept of thermal bridge has been evaluated on the basis of energy losses and environmental effects in the building.","PeriodicalId":267255,"journal":{"name":"International Journal of Chemistry and Technology","volume":"46 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139188839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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