Lack of FAS receptor expression in colorectal cancer patients correlates with high TNM staging

B. Laan
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Abstract

Cancer cells often inhibit the expression of FAS to evade T-cell mediated apoptosis upon HLA-mediated recognition. In this study, we aim to find the prognostic value of FAS expression, next to HLA expression, in colorectal cancer (CRC) patients. Colorectal tissue was immunohistochemically stained for the FAS and HLA receptors. Results show that there are significantly more patients with no FAS and HLA expressions in higher stages corresponding with tumor node metastasis (TNM) than in lower stages. Next to TNM stage, the loss of expression of FAS or of both FAS and HLA turns out to have no additional prognostic value.
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结直肠癌患者FAS受体表达缺乏与高TNM分期相关
癌细胞经常抑制FAS的表达,以逃避hla介导的t细胞介导的凋亡。在这项研究中,我们的目的是发现FAS表达在结直肠癌(CRC)患者中的预后价值,仅次于HLA表达。结直肠组织进行FAS和HLA受体免疫组织化学染色。结果显示,与肿瘤淋巴结转移(TNM)相对应的高分期患者FAS和HLA无表达明显多于低分期患者。在TNM期之后,FAS或FAS和HLA的表达缺失没有额外的预后价值。
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