Potency of the Natural Honey in Homeostasis of Four Liver enzymes in Rats Induced by Doxorubicin

Abstract

Previous histological studies have confirmed the curing potency of ingested natural honey on both liver and kidney’s cellular structures in mice and other experimental animals. Forty four male Wister rats were divided into four groups, control (G1); honey only (G2); Doxorubicin (DOX) (G3) and DOX with natural honey (G4), respectively. The experiments lasted 7 weeks following subcutaneous administrating 5mg/Kg b.wt./week of DOX and treatment with 1 mL/L honeyed water. Four most common liver enzymes e.g. Alkaline phosphatase (ALP), Alanine transaminase (ALT), Aspartate transaminase (AST) and Gamma-Glutamyl Transferase (GGT) in the blood as well as differential counting of WBC were tested to assess the impact of curing potency of the ingested natural honey via stabilizing the levels of the enzymes. The biochemical assessments have shown curing potency of natural honey against the toxicity impact of DOX on the above liver enzymes. Differential counting of WBC have shown insignificant changes in most WBCs but significant elevation of eosinophil in DOX rats (G3) in comparison with other groups indicating development of allergy. It has been concluded that lower or mild doses of DOX have less toxic effects on the body with a rather better impact of honey. Perhaps regular ingestion of the natural honey could provide a natural remedy on general health e.g. functions of the liver and positive impacts on other chronicle diseases. Further researches are recommended using higher doses of DOX via using other administration methods e.g. intravenous.