T. H. Hong, S. Choi, Jeong soo Kim, Kee-Hwan Kim, H. Seo, J. Kim, C. Ahn, W. Park, S. Oh, S. Jung, K. W. Lim
{"title":"The Clinical Application of Insulin-like Growth Factor-I Receptor (IGF-IR) and Insulin Receptor Substrate-1 (IRS-1) Expression in Breast Cancer","authors":"T. H. Hong, S. Choi, Jeong soo Kim, Kee-Hwan Kim, H. Seo, J. Kim, C. Ahn, W. Park, S. Oh, S. Jung, K. W. Lim","doi":"10.4048/JKBCS.2003.6.4.283","DOIUrl":null,"url":null,"abstract":"인슐린유사성장인자(Insulin-like Growth Factor (IGF))이다. stage, the histological grade, the estrogen receptor (ER) and the progesterone receptor (PR). Results: The results showed that IGF-IR and IRS-1 expression positively correlated with the ER and PR, and an inverse relationship was found between the IGF-IR and IRS-1 and histological grades. No association was observed between the IGR-IR and IRS-1 and the patent's age and clinical stage. In survival analysis, there was no definite association between the expressions of IGF-IR and IRS-1 and the disease free survival rate. Conclusion: IGF-IR and IRS-1 appear to play a role in the progression and differentiation of breast cancer in association with the ER and the PR. (Journal of Korean Breast Cancer Society 2003;6:283-290)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"40 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Breast Cancer Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4048/JKBCS.2003.6.4.283","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
인슐린유사성장인자(Insulin-like Growth Factor (IGF))이다. stage, the histological grade, the estrogen receptor (ER) and the progesterone receptor (PR). Results: The results showed that IGF-IR and IRS-1 expression positively correlated with the ER and PR, and an inverse relationship was found between the IGF-IR and IRS-1 and histological grades. No association was observed between the IGR-IR and IRS-1 and the patent's age and clinical stage. In survival analysis, there was no definite association between the expressions of IGF-IR and IRS-1 and the disease free survival rate. Conclusion: IGF-IR and IRS-1 appear to play a role in the progression and differentiation of breast cancer in association with the ER and the PR. (Journal of Korean Breast Cancer Society 2003;6:283-290)
。分期、组织学分级、雌激素受体(ER)和孕激素受体(PR)。结果:结果显示,IGF-IR、IRS-1表达与ER、PR呈正相关,与组织学分级呈反比关系。IGR-IR和IRS-1与患者的年龄和临床分期没有关联。在生存分析中,IGF-IR和IRS-1的表达与无病生存率没有明确的相关性。结论:IGF-IR和IRS-1似乎在乳腺癌的进展和分化中发挥作用,与ER和PR有关(Journal of Korean breast cancer Society 2003;6:283-290)。