Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.306
Tae Wan Kim, S. Kang, Jiyoung Park, S. Ko, M. Hur, H. Lee, S. Kang, J. Lee
46세의 여자 환자가 7개월 전부터 촉지되는 우측 액 와부의 종괴를 주소로 내원하였다. 처음 종괴가 발견되 었을 때는 강낭콩 크기의 유동성 있는 종괴였으나 점 차 크기가 증가되면서 내원 1개월 전부터는 약간의 압 통도 동반되었다고 하였다. 환자는 내원 2년 2개월 전 에 본원에서 유방암 검진으로 선별검사를 받았으며 당 시 이학적 검사와 유방 X선 검사는 정상이었다(Fig. 1). 그 후 별 이상 없이 지내다가 6개월 전 처음 상기 증상 을 주소로 본원에서 또 한 차례 검진을 실시하였으나 당시에는 액와부 피하의 피지낭종으로 판단하여 관찰 하기로 한 경력이 있었다. 가족력에서 특이소견은 없었 다. 내원 당시 시행한 이학적 검사에서 3×2.5 cm 정도 의 경계가 불규칙하고 고정된 양상의 단단한 종괴가 우측 액와부에 촉지되었다(Fig. 2). 내원 후 시행한 유 방 X선 촬영술에서 우측 액와부에 엽상형의 경계가 불 규칙한 종괴와 확장된 림프절이 관찰되었으며(Fig. 3), 유방 초음파 검사에서 우측 액와부에 20.9×18.6 mm 크기의 불규칙한 내부 저음영과 불명확한 경계를 가 지는 종괴와 몇 개의 확장된 림프절이 관찰되었다 책임저자:고승상, 서울시 중구 묵정동 1-19 ꂕ 100-380, 성균관대학교 의과대학 삼성제일병원 외과 Tel: 02-2000-7080, Fax: 02-2000-7791 E-mail: drkoss@skku.edu 접수일:2004년 10월 21일, 개재승인일:2004년 12월 6일 본 논문의 요지는 2004년 춘계외과학회에서 발표하였음. Invasive Ductal Carcinoma Arising from Axillary Accessory Breast Tae Wan Kim, Sang Wook Kang, Ji Young Park, Seung Sang Ko, Min Hee Hur, Hae Kyung Lee, Sung Soo Kang, and Jee Hyun Lee
一位46岁的女患者从7个月前开始将触地右侧腋窝的肿块送到住所。最初发现种块时是芸豆大小的流动的种块，但随着点差增大，在内院1个月前开始还伴有一些压痛。患者在来院2年零2个月前，在本院因乳房癌检查接受了筛选检查，当时理学检查和乳房X线检查都正常(Fig)。1).此后没有什么异常，6个月前首次将上述症状在本院进行了一次检查，但当时判断为腋窝皮下的皮脂囊肿，决定进行观察。在家族史上没有特别的发现。在内院当时进行的理学检查中，3×2.5厘米左右的边界不规则、固定形态的坚硬肿块触到了右侧液窝部位(Fig)。2)内院后实施的乳方X线摄影术中，观察到右侧腋窝处叶状边界不规则的肿块和扩张的淋巴结(Fig。3)、乳房超声检查在右侧额压20。9×18 . 6 mm大小的不规则内部低音和不明确的界限钟块和观察了几个扩张淋巴节责任作者:高僧奖,住在首尔中区贞洞1 - 19ꂕ100 - 380,成均馆医科大学三星第一医院外科tel: 02 - 2000 - 7080、fax: 02 - 2000 -)和e - mail:drkoss@skku.edu收到日期:2004年10月21日，批准日期:2004年12月6日本论文摘要发表于2004年春季外科学会。Invasive Ductal Carcinoma Arising from Axillary Accessory Breast Tae Wan Kim, Sang Wook Kang, Ji Young Park, Seung Sang Ko, Min Hee Hur, Hae Kyung Lee, Sung Soo Kang, and Jee Hyun Lee
{"title":"Invasive Ductal Carcinoma Arising from Axillary Accessory Breast","authors":"Tae Wan Kim, S. Kang, Jiyoung Park, S. Ko, M. Hur, H. Lee, S. Kang, J. Lee","doi":"10.4048/JKBCS.2004.7.4.306","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.306","url":null,"abstract":"46세의 여자 환자가 7개월 전부터 촉지되는 우측 액 와부의 종괴를 주소로 내원하였다. 처음 종괴가 발견되 었을 때는 강낭콩 크기의 유동성 있는 종괴였으나 점 차 크기가 증가되면서 내원 1개월 전부터는 약간의 압 통도 동반되었다고 하였다. 환자는 내원 2년 2개월 전 에 본원에서 유방암 검진으로 선별검사를 받았으며 당 시 이학적 검사와 유방 X선 검사는 정상이었다(Fig. 1). 그 후 별 이상 없이 지내다가 6개월 전 처음 상기 증상 을 주소로 본원에서 또 한 차례 검진을 실시하였으나 당시에는 액와부 피하의 피지낭종으로 판단하여 관찰 하기로 한 경력이 있었다. 가족력에서 특이소견은 없었 다. 내원 당시 시행한 이학적 검사에서 3×2.5 cm 정도 의 경계가 불규칙하고 고정된 양상의 단단한 종괴가 우측 액와부에 촉지되었다(Fig. 2). 내원 후 시행한 유 방 X선 촬영술에서 우측 액와부에 엽상형의 경계가 불 규칙한 종괴와 확장된 림프절이 관찰되었으며(Fig. 3), 유방 초음파 검사에서 우측 액와부에 20.9×18.6 mm 크기의 불규칙한 내부 저음영과 불명확한 경계를 가 지는 종괴와 몇 개의 확장된 림프절이 관찰되었다 책임저자:고승상, 서울시 중구 묵정동 1-19 ꂕ 100-380, 성균관대학교 의과대학 삼성제일병원 외과 Tel: 02-2000-7080, Fax: 02-2000-7791 E-mail: drkoss@skku.edu 접수일:2004년 10월 21일, 개재승인일:2004년 12월 6일 본 논문의 요지는 2004년 춘계외과학회에서 발표하였음. Invasive Ductal Carcinoma Arising from Axillary Accessory Breast Tae Wan Kim, Sang Wook Kang, Ji Young Park, Seung Sang Ko, Min Hee Hur, Hae Kyung Lee, Sung Soo Kang, and Jee Hyun Lee","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121449162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.251
Changxin Song, Seung Il Kim, Chan Heun Park
{"title":"The Analysis of HER-2/neu Gene Status and Correlation with Other Clinico-Pathologic Factors for Breast Cancer Using Tissue Microarray","authors":"Changxin Song, Seung Il Kim, Chan Heun Park","doi":"10.4048/JKBCS.2004.7.4.251","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.251","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121635585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.256
Nam Seop Lee, W. Park, Dong Ho Lee, B. Song, Jeong soo Kim, S. Oh, S. Jung, Jai Hak Lee
{"title":"Diagnosis of Non-palpable Breast Lesions with Microcalcification by Upright Add-on Type Stereotactic Vacuum-assisted Biopsy","authors":"Nam Seop Lee, W. Park, Dong Ho Lee, B. Song, Jeong soo Kim, S. Oh, S. Jung, Jai Hak Lee","doi":"10.4048/JKBCS.2004.7.4.256","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.256","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132390420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.263
S. Woo, Sangwoo Kim, Jeong-Han Kim, S. Nam, Jung-Hyun Yang
Purpose: A sentinel lymph node biopsy (SLNB) has become the standard care for the staging of axilla in breast cancer and the increase in body weight with age has an inverse relationship to its success. Therefore, the characteristics of patients who underwent a SLNB, and the relationship of the influences of Body Mass Index (BMI) and age, were evaluated using lymphoscintigram visualization in a sentinel lymph node biopsy (SLNB) for breast cancer. Methods: Between Sept. 1995 and Dec 2003, 238 patients underwent lymphoscintigraphy and SLNB (including full axillary node dissection with SLNB). 205 (86.1%) cases were able to be visualized by lymphoscintigraphy, But the remaining 33 (13.9%) were not. A combined technique (radioisotope and blue dye) was used to detect the SLNs. The BMI for each patient was calculated from height and weight data (kg/m). Results: A SLNB was attempted in all cases, but 5 failed. Of the 238 cases, the lymphoscintigraphy visualization was successful in 205 (86.1%) and failed in 33 (13.9%). The mean weight and BMI were significantly higher in the failure group. The success of a SLNB was inversely related to the BMI. When the subjects were divided into two group accoding to age (<50 year-old versus ≥50 year-old), this relationship was more pronounced in the ≥50 year-old group. Conclusion: The age and BMI of the patient influences the detection of the sentinel lymph node on a lymphoscintigram. There was no influence on the sentinel lymph node biopsy with increasing BMI and age. Therefore, increased age and/or BMI alone do not appear to be contraindication for a sentinel lymph node biopsy in older or overweight patients. (Journal of Korean Breast Cancer Society 2004;7:263-267) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Influences of Body Mass Index (BMI) and Age for Lymphoscintigraphy in Sentinel Lymph Node Detection with Breast Cancer","authors":"S. Woo, Sangwoo Kim, Jeong-Han Kim, S. Nam, Jung-Hyun Yang","doi":"10.4048/JKBCS.2004.7.4.263","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.263","url":null,"abstract":"Purpose: A sentinel lymph node biopsy (SLNB) has become the standard care for the staging of axilla in breast cancer and the increase in body weight with age has an inverse relationship to its success. Therefore, the characteristics of patients who underwent a SLNB, and the relationship of the influences of Body Mass Index (BMI) and age, were evaluated using lymphoscintigram visualization in a sentinel lymph node biopsy (SLNB) for breast cancer. Methods: Between Sept. 1995 and Dec 2003, 238 patients underwent lymphoscintigraphy and SLNB (including full axillary node dissection with SLNB). 205 (86.1%) cases were able to be visualized by lymphoscintigraphy, But the remaining 33 (13.9%) were not. A combined technique (radioisotope and blue dye) was used to detect the SLNs. The BMI for each patient was calculated from height and weight data (kg/m). Results: A SLNB was attempted in all cases, but 5 failed. Of the 238 cases, the lymphoscintigraphy visualization was successful in 205 (86.1%) and failed in 33 (13.9%). The mean weight and BMI were significantly higher in the failure group. The success of a SLNB was inversely related to the BMI. When the subjects were divided into two group accoding to age (<50 year-old versus ≥50 year-old), this relationship was more pronounced in the ≥50 year-old group. Conclusion: The age and BMI of the patient influences the detection of the sentinel lymph node on a lymphoscintigram. There was no influence on the sentinel lymph node biopsy with increasing BMI and age. Therefore, increased age and/or BMI alone do not appear to be contraindication for a sentinel lymph node biopsy in older or overweight patients. (Journal of Korean Breast Cancer Society 2004;7:263-267) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127717656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.228
H. Kang, S. Hong, B. Son, H. Yoon, G. Gong, S. Ahn
Purpose: Drug resistance plays an important role in the failure of chemotherapy in breast cancer. The purpose of the study was to investigate the chemosensitive and chemoresistance indices of breast carcinomas and see if the in vitro chemosensitivity test correlated with the prognostic indices. Methods: The immunohistochemical expressions of MDR1, MRP1 and topoisomerase IIα (topo IIα) were studied and then correlated these with the in vitro chemosensitivities using the histoculture drug response assay (HDRA) and clinicopathological factors in 51 breast carcinomas. Results: In the breast carcinomas examined, the immunohistochemical expressions of MDR1, MRP1 and topo IIα were strongly observed in 26 (51.0%), 16 (32.0%), 15 (31.3%) carcinomas, respectively. The MRP1 was more frequently expressed in poorly differentiated carcinomas (P= 0.006), and those of MDR1 and topo IIα were more frequently observed in tumor overexpressing cerbB2 (P=0.038, P=0.036). The expression of MDR1 was related to that of topo IIα (P=0.015). Comparing these markers with the in vitro chemosensitivities to cyclophosphamide, 5-FU, adriamycin, taxol and taxotere, no correlations were found between the expression of MDR1, MRP1, and topo IIα but from the chemosensitivity using the HDRA, the growth inhibition rate for cyclophosphamide was higher in MRP1 expressing carcinomas (P=0.009). Conclusion: MDR1, MRP1 and topo IIα were all found to be associated with the poor prognostic indices, but assessment of their immunohistochemical expressions did not allow for prediction of the response to chemotherapy by the in vitro chemosensitivity test in breast carcinomas. (Journal of Korean Breast Cancer Society 2004;7:228-235)
目的:耐药在乳腺癌化疗失败中起重要作用。本研究旨在探讨乳腺癌的化疗敏感和耐药指标，以及体外化疗敏感试验是否与预后指标相关。方法:采用组织培养药物反应试验(HDRA)和临床病理因素，研究51例乳腺癌组织中MDR1、MRP1和拓扑异构酶ⅱα (topoⅱα)的免疫组化表达，并将其与体外化疗敏感性进行相关性分析。结果:在乳腺癌中，MDR1、MRP1和topo i α的免疫组化表达分别在26例(51.0%)、16例(32.0%)、15例(31.3%)中表达。MRP1在低分化癌中表达较多(P= 0.006)， MDR1和topo i α在cerbB2过表达的肿瘤中表达较多(P=0.038, P=0.036)。MDR1的表达与topo i α的表达有相关性(P=0.015)。将这些标志物与体外对环磷酰胺、5-FU、阿霉素、紫杉醇和taxoere的化学敏感性进行比较，发现MDR1、MRP1和topo i α的表达之间没有相关性，但从HDRA的化学敏感性来看，表达MRP1的肿瘤对环磷酰胺的生长抑制率更高(P=0.009)。结论:MDR1、MRP1和topo i α均与乳腺癌预后不良指标相关，但其免疫组化表达的评估并不能通过体外化疗敏感性试验预测乳腺癌患者对化疗的反应。(韩国乳腺癌协会杂志2004;7:228-235)
{"title":"Correlation of Immunohistochemical Expression of MDR1, MRP1, Topoisomerase IIalpha with Prognostic Factors and Histoculture Drug Response Assay (HDRA) Result in Breast Carcinoma","authors":"H. Kang, S. Hong, B. Son, H. Yoon, G. Gong, S. Ahn","doi":"10.4048/JKBCS.2004.7.4.228","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.228","url":null,"abstract":"Purpose: Drug resistance plays an important role in the failure of chemotherapy in breast cancer. The purpose of the study was to investigate the chemosensitive and chemoresistance indices of breast carcinomas and see if the in vitro chemosensitivity test correlated with the prognostic indices. Methods: The immunohistochemical expressions of MDR1, MRP1 and topoisomerase IIα (topo IIα) were studied and then correlated these with the in vitro chemosensitivities using the histoculture drug response assay (HDRA) and clinicopathological factors in 51 breast carcinomas. Results: In the breast carcinomas examined, the immunohistochemical expressions of MDR1, MRP1 and topo IIα were strongly observed in 26 (51.0%), 16 (32.0%), 15 (31.3%) carcinomas, respectively. The MRP1 was more frequently expressed in poorly differentiated carcinomas (P= 0.006), and those of MDR1 and topo IIα were more frequently observed in tumor overexpressing cerbB2 (P=0.038, P=0.036). The expression of MDR1 was related to that of topo IIα (P=0.015). Comparing these markers with the in vitro chemosensitivities to cyclophosphamide, 5-FU, adriamycin, taxol and taxotere, no correlations were found between the expression of MDR1, MRP1, and topo IIα but from the chemosensitivity using the HDRA, the growth inhibition rate for cyclophosphamide was higher in MRP1 expressing carcinomas (P=0.009). Conclusion: MDR1, MRP1 and topo IIα were all found to be associated with the poor prognostic indices, but assessment of their immunohistochemical expressions did not allow for prediction of the response to chemotherapy by the in vitro chemosensitivity test in breast carcinomas. (Journal of Korean Breast Cancer Society 2004;7:228-235)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129559495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.299
E. Park, Y. Jeon, Sang-Ick Han, S. Oh
Purpose: This study was designed to explore the quality of life (QOL) for breast cancer patients who survived after operation by using the World Health Organization Quality of Life (WHOQOL) instrument-Korean version. Methods: Fifty patients with breast cancer were recruited after their operations, and an informed consent was obtained from each of them. Hospital staff members served as the controls. The 100 item-WHOQOL instrument included questions on the physical, psychological, social, independence, environmental and spiritual domains, and it was employed for testing the all subjects. Results: The physical, psychological, independence and social domains were shown to have a worsened quality of life for patients with breast cancer who survive after their operations. Quality of life in the physical and social domains were perceived as worse by patients having advanced stage tumor, with mastectomy. Patients with mastectomy who survived their cancer felt a worse quality of life in the psychological domain. The quality of life scores for patients having advanced stage tumor with mastectomy, during the early postoperative period (≤2 years) was lower for the independence domain. Patients at middle postoperative period (2∼5years) felt a better quality of life in spiritual domain. Conclusion: Not only is the objective medical success important to female breast cancer survivors, but the individual subjective perception of their condition is also important. The psychological status of these women needs to be considered when managing patients with breast cancer after their surgical operation. In this context, the WHOQOL reflects a measurement of a multi-dimensional state of wellbeing, and it could be a useful tool across a variety of cultural and value systems in the world. (Journal of Korean Breast Cancer Society 2004;7:299-305)
{"title":"A Preliminary Study on the Quality of Life for Patients Who Had Breast Cancer Operations","authors":"E. Park, Y. Jeon, Sang-Ick Han, S. Oh","doi":"10.4048/JKBCS.2004.7.4.299","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.299","url":null,"abstract":"Purpose: This study was designed to explore the quality of life (QOL) for breast cancer patients who survived after operation by using the World Health Organization Quality of Life (WHOQOL) instrument-Korean version. Methods: Fifty patients with breast cancer were recruited after their operations, and an informed consent was obtained from each of them. Hospital staff members served as the controls. The 100 item-WHOQOL instrument included questions on the physical, psychological, social, independence, environmental and spiritual domains, and it was employed for testing the all subjects. Results: The physical, psychological, independence and social domains were shown to have a worsened quality of life for patients with breast cancer who survive after their operations. Quality of life in the physical and social domains were perceived as worse by patients having advanced stage tumor, with mastectomy. Patients with mastectomy who survived their cancer felt a worse quality of life in the psychological domain. The quality of life scores for patients having advanced stage tumor with mastectomy, during the early postoperative period (≤2 years) was lower for the independence domain. Patients at middle postoperative period (2∼5years) felt a better quality of life in spiritual domain. Conclusion: Not only is the objective medical success important to female breast cancer survivors, but the individual subjective perception of their condition is also important. The psychological status of these women needs to be considered when managing patients with breast cancer after their surgical operation. In this context, the WHOQOL reflects a measurement of a multi-dimensional state of wellbeing, and it could be a useful tool across a variety of cultural and value systems in the world. (Journal of Korean Breast Cancer Society 2004;7:299-305)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125780287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.294
M. Chang
Purpose: Breast cancer risk assessment tools have been developed in western countries as a result of large scaled epidemiological studies. These tools have been used as a rationale for breast cancer screening and to determine the selection criteria of NSABP P-1 and P-2. The aim of this study was to develop a breast cancer risk assessment tool for Korean women, which would be helpful for screening and preventing breast cancer. Methods: The breast cancer risk model was used published by Sue Kyung Park in 2003. The report was a casecontrol study of 1687 breast cancer patients and 1155 normal populations in 3 hospitals from 1996 to 2000. The risk factors used in this model were age, family history of the first and second relatives, body mass index, age at the first delivery, breast-feeding and a special test on the breasts. A computer program was developed using the Borland Delphi on a personal computer using a windows 98 operating system. The program consisted of three parts; an input window of the risk factors, a calculation part of the relative risks, an output window of the results. Results: The program was a 308K byte sized single executable file. In the initial window, a simple explanation of the program and a reference of the risk model were displayed. The age, height and weight were entered as continuous variables in the input window. The family history of the first and second relatives, the age at the first delivery, breast-feeding and a special test on the breasts were selected by the radio buttons. In the output window, the relative risks were calculated according to each risk factor. The overall relative risk was calculated in a given age group and the overall age group. Conclusion: In this study, a computer program for a breast cancer risk assessment was developed using the relative risk model of breast cancer. This program was found to be useful for making an individual breast cancer risk assessment of Korean women. (Journal of Korean Breast Cancer Society 2004;7:294-298)
{"title":"Estimating Relative Risk of Breast Cancer in Korean Women Using Computer Program","authors":"M. Chang","doi":"10.4048/JKBCS.2004.7.4.294","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.294","url":null,"abstract":"Purpose: Breast cancer risk assessment tools have been developed in western countries as a result of large scaled epidemiological studies. These tools have been used as a rationale for breast cancer screening and to determine the selection criteria of NSABP P-1 and P-2. The aim of this study was to develop a breast cancer risk assessment tool for Korean women, which would be helpful for screening and preventing breast cancer. Methods: The breast cancer risk model was used published by Sue Kyung Park in 2003. The report was a casecontrol study of 1687 breast cancer patients and 1155 normal populations in 3 hospitals from 1996 to 2000. The risk factors used in this model were age, family history of the first and second relatives, body mass index, age at the first delivery, breast-feeding and a special test on the breasts. A computer program was developed using the Borland Delphi on a personal computer using a windows 98 operating system. The program consisted of three parts; an input window of the risk factors, a calculation part of the relative risks, an output window of the results. Results: The program was a 308K byte sized single executable file. In the initial window, a simple explanation of the program and a reference of the risk model were displayed. The age, height and weight were entered as continuous variables in the input window. The family history of the first and second relatives, the age at the first delivery, breast-feeding and a special test on the breasts were selected by the radio buttons. In the output window, the relative risks were calculated according to each risk factor. The overall relative risk was calculated in a given age group and the overall age group. Conclusion: In this study, a computer program for a breast cancer risk assessment was developed using the relative risk model of breast cancer. This program was found to be useful for making an individual breast cancer risk assessment of Korean women. (Journal of Korean Breast Cancer Society 2004;7:294-298)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125799633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.268
I. Lee, Seung Ah Lee, Joon Jeong, Byeong-Woo Park, W. Jung, S. Hong, K. Oh, Y. H. Ryu, H. Lee
Purpose: The need for completion axillary lymph node dissection, even in early breast cancer patients with a positive sentinel lymph node, has been questioned. The purpose of this study was to determine the factors that predict the presence of metastasis in non-sentinel lymph nodes (NSLNs) when the sentinel lymph node (SLN) was positive. Methods: Between December 1998 and June 2004, the records of 104 early breast cancer patients with a positive SLN and who underwent completion axillary lymph node dissection were reviewed. The clinicopathological features in SLN-positive patients were evaluated as possible predictors of metastatic NSLN. Results: Forty four (42.3%) of the 104 patients with positive SLN had metastatic NSLNs. In a univariate analysis, unicentric multifocality (P=0.016), lymphovascular invasion (P=0.006) and SLN metastasis larger than 2 mm (P= 0.003) were associated with positive NSLN findings. The number of SLNs removed was significantly associated as a negative predictor (P=0.043). A multivariate analysis revealed that SLN metastasis >2 mm (P=0.021) and lymphovascular invasion (P=0.040) were independent predictors of metastatic NSLN. Conclusion: The likelihood of metastatic NSLNs correlates with the size of the largest SLN metastasis and the presence of lymphovascular invasion of the primary tumor. Even though in early breast cancer with positive SLNs, incorporating these factors may help determining which patients would benefit from additional axillary lymph node dissection. (Journal of Korean Breast Cancer Society 2004;7:268-274)
目的:即使在前哨淋巴结阳性的早期乳腺癌患者中，是否需要完全性腋窝淋巴结清扫一直受到质疑。本研究的目的是确定当前哨淋巴结(SLN)阳性时，预测非前哨淋巴结(nsln)转移存在的因素。方法:回顾性分析1998年12月至2004年6月间104例SLN阳性的早期乳腺癌患者行完全性腋窝淋巴结清扫术。评估sln阳性患者的临床病理特征作为转移性NSLN的可能预测因素。结果:104例SLN阳性患者中44例(42.3%)为转移性nsln。在单变量分析中，单中心多灶性(P=0.016)、淋巴血管浸润(P=0.006)和SLN转移大于2 mm (P= 0.003)与NSLN阳性结果相关。sln切除数量作为负向预测因子显著相关(P=0.043)。多因素分析显示，SLN转移>2 mm (P=0.021)和淋巴血管浸润(P=0.040)是转移性NSLN的独立预测因素。结论:nsln转移的可能性与最大的SLN转移的大小和原发肿瘤是否存在淋巴血管浸润有关。即使在sln阳性的早期乳腺癌中，结合这些因素可能有助于确定哪些患者将受益于额外的腋窝淋巴结清扫。(韩国乳腺癌协会杂志2004;7:268-274)
{"title":"Predicting the Status of the Nonsentinel Lymph Nodes in early Breast Cancer Patients with Positive Sentinel Lymph Nodes","authors":"I. Lee, Seung Ah Lee, Joon Jeong, Byeong-Woo Park, W. Jung, S. Hong, K. Oh, Y. H. Ryu, H. Lee","doi":"10.4048/JKBCS.2004.7.4.268","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.268","url":null,"abstract":"Purpose: The need for completion axillary lymph node dissection, even in early breast cancer patients with a positive sentinel lymph node, has been questioned. The purpose of this study was to determine the factors that predict the presence of metastasis in non-sentinel lymph nodes (NSLNs) when the sentinel lymph node (SLN) was positive. Methods: Between December 1998 and June 2004, the records of 104 early breast cancer patients with a positive SLN and who underwent completion axillary lymph node dissection were reviewed. The clinicopathological features in SLN-positive patients were evaluated as possible predictors of metastatic NSLN. Results: Forty four (42.3%) of the 104 patients with positive SLN had metastatic NSLNs. In a univariate analysis, unicentric multifocality (P=0.016), lymphovascular invasion (P=0.006) and SLN metastasis larger than 2 mm (P= 0.003) were associated with positive NSLN findings. The number of SLNs removed was significantly associated as a negative predictor (P=0.043). A multivariate analysis revealed that SLN metastasis >2 mm (P=0.021) and lymphovascular invasion (P=0.040) were independent predictors of metastatic NSLN. Conclusion: The likelihood of metastatic NSLNs correlates with the size of the largest SLN metastasis and the presence of lymphovascular invasion of the primary tumor. Even though in early breast cancer with positive SLNs, incorporating these factors may help determining which patients would benefit from additional axillary lymph node dissection. (Journal of Korean Breast Cancer Society 2004;7:268-274)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127739419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.236
Jun Ho Jang, Tae Yoon Kim, S. Kim, M. Baek, M. Oh, E. Kim, Moon-Soo Lee, Chang Ho Kim, Min-Hyuk Lee, M. Cho
Purpose: Survivin is a member of the inhibitor of apoptosis (IAP) family, which is also involved in the regulation of cell division and is also overexpressed and associated with parameters of poor prognosis in most human cancers, including carcinomas of the lung, breast, colon, stomach, esophagus and pancreas. This study examined the expression patterns of survivin in normal breast tissue, atypical hyperplasia, primary breast cancer and lymph node tissues involved with breast cancer and to determined whether the expression of survivin is associated with the characteristics and prognosis of breast cancer. Methods: Formalin-fixed paraffin-embedded samples from 80 breast cancer, 20 atypical hyperplasia and 20 malignant lymph node tissue cases were immunostained using polyclonal survivin (Novus Biologicals, CO). The degree of immunostaining was recorded on a scale of 0-3 according to the percentages of staining and distributions within the cytoplasm & nucleus. Results: Survivin was expressed in 52, 14 and 17 of the 80 breast cancer (65%), atypical hyperplasia (70%) and breast cancer lymphoid (85%) specimens respectively. Among those expressing cancer, 11.3, 31.3 and 22.5% demonstrated nuclear staining only, cytoplasmic staining only and both nuclear and cytoplasmic staining respectively. A statistical analysis revealed that cytoplasmic survivin expression was correlated with the stage, histological grade and L/N metastasis. In a Cox proportional hazard model analysis, the expression of survivin was not identified as a significant independent predictor of overall survival (P=0.168), although the decrease in the survival rate of survivin-positive patients did reach statistical significance (P=0.048). Conclusion: Our results show that survivin is frequently overexpressed in primary breast cancer and its expression gradually increased from normal breast tissue to malignant lymph nodes. The expression of cytoplasmic survivin was common in breast cancer and could be both a useful diagnostic marker and important source of prognostic information. (Journal of Korean Breast Cancer Society 2004;7:236243)
目的:Survivin是凋亡抑制剂(inhibitor of apoptosis, IAP)家族的一员，参与细胞分裂的调控，在大多数人类癌症(包括肺癌、乳腺癌、结肠癌、胃癌、食管癌和胰腺癌)中也存在过表达并与不良预后参数相关。本研究通过检测survivin在正常乳腺组织、非典型增生组织、原发性乳腺癌及乳腺癌相关淋巴结组织中的表达规律，探讨survivin的表达是否与乳腺癌的特征及预后相关。方法:采用多克隆survivin (Novus Biologicals, CO)对80例乳腺癌、20例非典型增生和20例恶性淋巴结组织进行福尔马林固定石蜡包埋的免疫染色。根据染色百分率及细胞质和细胞核内的分布情况，以0-3级记分免疫染色程度。结果:80例乳腺癌中有52例表达Survivin, 14例表达Survivin, 17例表达Survivin，占65%，不典型增生占70%，乳腺癌淋巴样组织占85%。在表达癌的患者中，分别有11.3、31.3和22.5%的患者仅表现为核染色，31.3和22.5%的患者仅表现为细胞质染色，细胞核和细胞质均表现为染色。统计分析显示，胞质survivin表达与肿瘤分期、组织学分级及L/N转移相关。在Cox比例风险模型分析中，虽然survivin阳性患者的生存率下降有统计学意义(P=0.048)，但survivin的表达并未被确定为总生存率的显著独立预测因子(P=0.168)。结论:survivin在原发性乳腺癌中频繁过表达，从正常乳腺组织到恶性淋巴结表达逐渐升高。细胞质survivin的表达在乳腺癌中很常见，是一种有用的诊断标志物和预后信息的重要来源。(韩国乳腺癌协会杂志2004;7:236243)
{"title":"Expression of Survivin in Patients with Breast Cancer","authors":"Jun Ho Jang, Tae Yoon Kim, S. Kim, M. Baek, M. Oh, E. Kim, Moon-Soo Lee, Chang Ho Kim, Min-Hyuk Lee, M. Cho","doi":"10.4048/JKBCS.2004.7.4.236","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.236","url":null,"abstract":"Purpose: Survivin is a member of the inhibitor of apoptosis (IAP) family, which is also involved in the regulation of cell division and is also overexpressed and associated with parameters of poor prognosis in most human cancers, including carcinomas of the lung, breast, colon, stomach, esophagus and pancreas. This study examined the expression patterns of survivin in normal breast tissue, atypical hyperplasia, primary breast cancer and lymph node tissues involved with breast cancer and to determined whether the expression of survivin is associated with the characteristics and prognosis of breast cancer. Methods: Formalin-fixed paraffin-embedded samples from 80 breast cancer, 20 atypical hyperplasia and 20 malignant lymph node tissue cases were immunostained using polyclonal survivin (Novus Biologicals, CO). The degree of immunostaining was recorded on a scale of 0-3 according to the percentages of staining and distributions within the cytoplasm & nucleus. Results: Survivin was expressed in 52, 14 and 17 of the 80 breast cancer (65%), atypical hyperplasia (70%) and breast cancer lymphoid (85%) specimens respectively. Among those expressing cancer, 11.3, 31.3 and 22.5% demonstrated nuclear staining only, cytoplasmic staining only and both nuclear and cytoplasmic staining respectively. A statistical analysis revealed that cytoplasmic survivin expression was correlated with the stage, histological grade and L/N metastasis. In a Cox proportional hazard model analysis, the expression of survivin was not identified as a significant independent predictor of overall survival (P=0.168), although the decrease in the survival rate of survivin-positive patients did reach statistical significance (P=0.048). Conclusion: Our results show that survivin is frequently overexpressed in primary breast cancer and its expression gradually increased from normal breast tissue to malignant lymph nodes. The expression of cytoplasmic survivin was common in breast cancer and could be both a useful diagnostic marker and important source of prognostic information. (Journal of Korean Breast Cancer Society 2004;7:236243)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124478317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.244
S. Kim, Tae Yoon Kim, Jae J Kim, Chang Ho Kim, O. Song, M. H. Lee, E. Kim, M. Cho
Purpose: Breast cancer is a common malignant tumor for Korean women. Various oncogenes have been demonstrated in malignant tumor cells. There were many reports on the relationship between the prognosis and the tumor markers, and particularly for HER-2/neu; however, this relationship is controversial. The aim of this study was to perform immunohistochemical staining for the HER-2/neu antigenic protein in breast cancer patients to evaluate the expression rate of this antigenic protein, and to compare the correlations with the patients' prognosis. Methods: The medical records of 100 patients who were diagnosed with breast cancer and who were treated with mastectomy between January 1996 and December 1999 at Soonchunhyang University Cheonan Hospital were selected according to the tissue condition of the paraffin block fixations. The prognostic factors were then investigated. The immunohistochemical expression of HER-2/neu was examined and compared with the survival rate using a Kaplan-Meier estimate and a log rank test. Results: One hundred patients were included in this study, had a mean (SD) age of 47.9 (plus or minus 10.5) years and a follow-up duration of 59.9 (plus or minus 13.3) moths The overall mortality was 35% (35/100) and the mean survival time (SD) was 64.4 (plus or minus 12.0) months. The overall 5-year survival rate was 77.0%. Among the study variables, the tumor stage was a significant predictor of survival, and it as associate with a significantly low survival rate for stage III tumor. Lymph node metastasis, hormonal receptor status, histologic grade and HER-2/neu overexpression were significantly associated with the survival rate for patients with breast cancer. Conclusion: HER-2/neu is a very useful prognostic factor, and statistical significance was achieved for this factor. (Journal of Korean Breast Cancer Society 2004;7:244250)
{"title":"Clinical Correlation of HER-2/neu Overexpression in Patients with Breast Cancer","authors":"S. Kim, Tae Yoon Kim, Jae J Kim, Chang Ho Kim, O. Song, M. H. Lee, E. Kim, M. Cho","doi":"10.4048/JKBCS.2004.7.4.244","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.244","url":null,"abstract":"Purpose: Breast cancer is a common malignant tumor for Korean women. Various oncogenes have been demonstrated in malignant tumor cells. There were many reports on the relationship between the prognosis and the tumor markers, and particularly for HER-2/neu; however, this relationship is controversial. The aim of this study was to perform immunohistochemical staining for the HER-2/neu antigenic protein in breast cancer patients to evaluate the expression rate of this antigenic protein, and to compare the correlations with the patients' prognosis. Methods: The medical records of 100 patients who were diagnosed with breast cancer and who were treated with mastectomy between January 1996 and December 1999 at Soonchunhyang University Cheonan Hospital were selected according to the tissue condition of the paraffin block fixations. The prognostic factors were then investigated. The immunohistochemical expression of HER-2/neu was examined and compared with the survival rate using a Kaplan-Meier estimate and a log rank test. Results: One hundred patients were included in this study, had a mean (SD) age of 47.9 (plus or minus 10.5) years and a follow-up duration of 59.9 (plus or minus 13.3) moths The overall mortality was 35% (35/100) and the mean survival time (SD) was 64.4 (plus or minus 12.0) months. The overall 5-year survival rate was 77.0%. Among the study variables, the tumor stage was a significant predictor of survival, and it as associate with a significantly low survival rate for stage III tumor. Lymph node metastasis, hormonal receptor status, histologic grade and HER-2/neu overexpression were significantly associated with the survival rate for patients with breast cancer. Conclusion: HER-2/neu is a very useful prognostic factor, and statistical significance was achieved for this factor. (Journal of Korean Breast Cancer Society 2004;7:244250)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124197693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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