A high voltage stimulator using a low-Q class-E pulsed radiofrequency driver for animal study of relieving trigeminal neuralgia pain

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI:10.1109/ISBB.2014.6820891

Chien-Chi Lu, W. Tseng, Y. Tseng, Shi-Hang Lin, Kun-Ying Yeh, Shey-Shi Lu, C. Yen, M. Lin, Hung-Wei Chiu

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Abstract

In this work, an in vivo animal experiment was conducted to show that the pulsed radiofrequency (PRF) stimulation in relieving pain is effective for trigeminal neuralgia. The experiment also reveals that the 10-V stimulation is more effective than 5-V stimulation. Hence, in order to generate a high PRF voltage in a brain stimulator, a low-Q class-E amplifier is proposed to be a high voltage electrical stimulation (ES) driver by controlling the input duty cycle. The steady states of the circuit waveform are represented in two PDEs' and are numerically solved in math tool to achieve circuit parameters. When the driver was operated under the condition of Q = 1 and D = 0.8, the output peak voltage was measured up to 10 V, which is 3 times of VDD. The conversion efficiency of the PRF driver was measured 90% that measured load from 300Ω to 1.8kΩ. The efficiency of the low-Q operation is found to be better under mismatched load than in high-Q operation.

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一种使用低q e类脉冲射频驱动器的高压刺激器，用于缓解三叉神经痛的动物研究

本研究通过动物体内实验，验证了脉冲射频(PRF)刺激对三叉神经痛的镇痛效果。实验还表明，10v刺激比5v刺激更有效。因此，为了在脑刺激器中产生高PRF电压，提出了一种低q的e类放大器，通过控制输入占空比作为高压电刺激(ES)驱动器。电路波形的稳态用两个偏微分方程表示，并用数学工具进行数值求解，得到电路参数。当驱动器在Q = 1, D = 0.8的条件下工作时，测得输出峰值电压高达10 V，是VDD的3倍。PRF驱动器的转换效率为90%，测量负载从300Ω到1.8kΩ。结果表明，在负载不匹配情况下，低q操作的效率优于高q操作。

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2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)

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