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2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)最新文献

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Stereoscopic laparoscopy using depth information from 3D model 立体腹腔镜使用深度信息从三维模型
Atul Kumar, Yen-Yu Wang, Ching-Jen Wu, Kai-Che Liu, Hurng-Sheng Wu
Laparoscopic surgery is indispensable from the current surgical procedures. Conventional laparoscope (endoscope) systems produce 2D colored video images which do not provide surgeons an actual depth perception of the scene. In this work, the problem was formulated as synthesizing a stereo image of the monocular (conventional) laparoscope image by incorporating into them the depth information from a 3D CT model. The current method was applied to the laparoscope video at the rate of up to 5 frames per second to visualize its stereo video. Correlation coefficients between the depth maps calculated with our method with those from the shape from shading algorithm were within the range of 0.70 to 0.95 (P <; 0.05).
腹腔镜手术是目前外科手术中不可缺少的。传统的腹腔镜(内窥镜)系统产生2D彩色视频图像,不能为外科医生提供对场景的实际深度感知。在这项工作中,该问题被表述为通过将3D CT模型的深度信息合并到单眼(传统)腹腔镜图像的立体图像中。将该方法应用于腹腔镜视频中,以高达5帧/秒的速度实现其立体视频的可视化。用我们的方法计算的深度图与用shape from shading算法计算的深度图的相关系数在0.70 ~ 0.95之间(P <;0.05)。
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引用次数: 2
Chip design of a 5.6-GHz 1-V wide tuning range frequency synthesizer with Gm-boosting Colpitts VCO for biomedical application 生物医学应用5.6 ghz 1 v宽调谐范围频率合成器的芯片设计与gm -boost Colpitts VCO
Jhin-Fang Huang, W. Lai, Jia-Lun Yang
A 5.6-GHz 1-V wide tuning range frequency synthesizer with a gain-boosting Colpitts voltage-controlled oscillator (VCO) is fabricated in TSMC 0.18 um CMOS process. In this prototype, there are two important features. First, a 1-V gain-boosting Colpitts LC VCO circuit is adopted to reduce phase noise and power consumption. Second, a class-AB current mode logic (CML) circuit is utilized in first divider stage to deal with the high frequency signal. At the supply voltages of 1-V for VCO and 1.8-V for digital circuits, measured results achieve that the VCO output frequency is tunable from 5.13~5.98 GHz corresponding to 15.4% and the locked phase noise is -105.83 dBc/Hz at 1MHz from 5.15 GHz. The power consumption is 5.6 mW and including pads, the chip area is 0.632 (0.89 × 0.71) mm2. This chip design low power consumption for biomedical application.
采用台积电0.18 um CMOS工艺制备了一种5.6 ghz 1 v宽调谐范围频率合成器,该合成器具有增益增强的Colpitts压控振荡器(VCO)。在这个原型中,有两个重要的特性。首先,采用1 v升压增益的Colpitts LC压控振荡器电路,降低相位噪声和功耗。其次,在第一分频级采用ab类电流模式逻辑(CML)电路处理高频信号。在VCO电源电压为1 v,数字电路电源电压为1.8 v时,测量结果表明,VCO输出频率在5.13~5.98 GHz范围内可调,对应于15.4%,锁相噪声在5.15 GHz范围内为-105.83 dBc/Hz。功耗为5.6 mW,加上焊盘,芯片面积为0.632 (0.89 × 0.71) mm2。该芯片设计为低功耗生物医学应用。
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引用次数: 26
Conceptual map and technological framework to manage dementia wandering 管理痴呆漫游的概念地图和技术框架
N. K. Vuong, Syin Chan, C. Lau
Wandering is one of the most common disruptive behaviors in people with dementia (PWD). Dementia wandering is a subject of study and research in the field of gerontology for more than 3 decades. The topic has then drawn the attention of technologists and particularly computer scientists since early 2000. Though a number of solutions and applications have been proposed and implemented to manage wandering, not many are widely used in practice due to 2 reasons. First, technologists' understanding and perception of wandering do not align with those of gerontologists. This consequently lowers the chance of proposed solutions to be accepted for clinical applications. Second, most solutions do not address all the dimensions of dementia wandering. Few applications cater the needs of other stakeholders involved including caregivers, physicians and researchers. This paper aims to bridge the knowledge gaps between gerontologists and technologists. We first present a conceptual map of wandering science from the perspectives of gerontologists. Then we provide a framework which identifies main threads of technologies that can be further developed to manage dementia wandering. We hope that the conceptual map and technological framework will guide technologists in developing relevant and essential assistive solutions which are not only widely used in clinical practice but also address the needs of all the parties involved.
徘徊是痴呆症患者最常见的破坏性行为之一。失智徘徊是老年学领域三十多年来研究的课题。自2000年初以来,这个话题引起了技术专家,尤其是计算机科学家的注意。虽然已经提出并实施了许多解决方案和应用程序来管理流浪,但由于两个原因,在实践中得到广泛应用的并不多。首先,技术专家对流浪的理解和感知与老年医学专家并不一致。因此,这降低了建议的解决方案被临床应用接受的机会。其次,大多数解决方案并不能解决痴呆症漫游的所有方面。很少有应用程序满足其他利益相关者的需求,包括护理人员、医生和研究人员。本文旨在弥合老年学家和技术专家之间的知识差距。我们首先从老年学家的角度提出了漫游科学的概念图。然后,我们提供了一个框架,该框架确定了可以进一步开发的技术主线,以管理痴呆徘徊。我们希望概念图和技术框架将指导技术人员开发相关的和必要的辅助解决方案,不仅在临床实践中广泛使用,而且满足各方的需求。
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引用次数: 2
A low power high CMRR CMOS instrumentation amplifier for Bio-impedance Spectroscopy 用于生物阻抗光谱的低功率高CMRR CMOS仪器放大器
Angelito A. Silverio, Wen-Yaw Chung, Vincent F. S. Tsai
In this paper, a high Common-Mode Rejection Ratio (CMRR) and low power CMOS Instrumentation Amplifier (IA) for use in Bio-impedance Spectroscopy (BIS) is presented. It consists of a complementary Differential Voltage - Current Conveyor (DVCC) that provides the common-mode signal rejection and high input impedance, a Folded - Cascode Operational Transconductance Amplifier (FC-OTA) that serves as a gain stage, and a high pass filter built using a PMOS pseudo-resistor. The IA was implemented using TSMC 0.35μm 2P4M Polycide Technology and simulations were carried out using HSPICE. The designed IA features a CMRR of 120.2dB, a differential input impedance of 102.3MΩ, and a common-mode input impedance of 41.3MΩ both at 50kHz, while dissipating an average static power of 290μW.
本文介绍了一种用于生物阻抗光谱(BIS)的高共模抑制比(CMRR)和低功耗CMOS仪表放大器(IA)。它包括一个互补的差分电压-电流传送带(DVCC),提供共模信号抑制和高输入阻抗,一个折叠级联代码操作跨导放大器(FC-OTA)作为增益级,以及一个使用PMOS伪电阻构建的高通滤波器。采用台积电0.35μm 2P4M多晶片技术实现了该系统,并利用HSPICE进行了仿真。所设计的IA在50kHz时的CMRR为120.2dB,差分输入阻抗为102.3MΩ,共模输入阻抗为41.3MΩ,平均静态功耗为290μW。
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引用次数: 8
A low-power super-regenerative BFSK transceiver for intelligent healthcare monitoring system 一种用于智能医疗监测系统的低功耗超再生BFSK收发器
Liang-Hung Wang, Tsung-Yen Chen, Kuang-Hao Lin, Shuenn-Yuh Lee
The present is proposed a low power RF-transceiver included a receiver and a transmitter. A gain amplifier and a supper regenerative divider construct an RF receiver; a voltage controlled oscillator (VCO) and a one stage power amplifier (PA) consist an RF transmitter. The digital modulation, binary frequency shift-keying (BFSK), is employed to modulate a wireless communication signal for proposed interactive intelligent healthcare monitoring system (IIHMS). The gain amplifier of RF receiver is biased in sub-threshold region for low power application. The proposed RF transceiver implemented in TSMC 0.18-μm 1P6M standard CMOS process with a chip area of 2.47 mm2. The measurement results show that the power consumption of the RF transmitter and receiver are 2.34 mW and 1.26 mW, respectively, under the lower supply voltage of 1.2 V.
提出了一种低功耗射频收发器,包括一个接收机和一个发射机。增益放大器和超再生分压器构成射频接收机;一个压控振荡器(VCO)和一个一级功率放大器(PA)组成一个射频发射机。在交互式智能健康监测系统(IIHMS)中,采用数字调制二元频移键控(BFSK)调制无线通信信号。在低功耗应用中,射频接收机的增益放大器偏置在亚阈值区域。该射频收发器采用台积电0.18 μm 1P6M标准CMOS工艺,芯片面积为2.47 mm2。测量结果表明,在较低的电源电压为1.2 V时,射频发射器和接收器的功耗分别为2.34 mW和1.26 mW。
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引用次数: 4
On the gene group problem 关于基因群问题
Sheng-Lung Peng, Yu-Lian Tang, Guanling Lee, Wei-Chun Liao
The analysis of gene networks is one of the hardest works in microarray analysis. Due to a lot of gene connection relations, it is complicated to analyze gene networks for understanding the evolution and functions of genomes. Gene team is a model for conserved gene clusters. However, it is defined on a genome of linear structure. In this paper, by transforming a gene network to a graph, we propose the concept of a gene group, i.e., closed genes according to their functions. An experimental study is proposed. We think this graph approach may be useful for finding closed genes.
基因网络分析是微阵列分析中最困难的工作之一。由于存在大量的基因连接关系,分析基因网络对于理解基因组的进化和功能是非常复杂的。基因组是保守基因簇的一个模型。然而,它是在线性结构的基因组上定义的。本文通过将基因网络转化为图,提出了基因群的概念,即按功能划分的封闭基因。提出了一项实验研究。我们认为这种图表方法可能对寻找封闭基因有用。
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引用次数: 0
Smart cane: Instrumentation of a quad cane with audio-feedback monitoring system for partial weight-bearing support 智能手杖:带有音频反馈监控系统的四根手杖的仪器,用于部分承重支撑
Joseph Mercado, Gemmilyn Chu, Erika Jane Imperial, Kelvin George Monje, Rae Mart Pabustan, Angelito A. Silverio
Proper cane handling is one of the main goals of cane therapy in the field of physical rehabilitation. Toward that goal, a system has been developed to monitor the weight-bearing performance of the patient and provide an audio feedback to affect a patient's weight application onto the cane. The smart cane is designed to read the force measurement, to compare the read-out force and to generate an alert message if the force applied by the patient is incorrect. The system includes a graphical user interface, which allows real-time graphing of the force measurements and keeps a database for offline comparative data analysis by the therapist. It employs a wireless connection between the microcontroller and the computer using Bluetooth technology, which increases mobility of the patient. This will help the patient to achieve optimum rehabilitation that can lead to an improved balance in walking and eventually cane independence.
拐杖的正确使用是拐杖治疗在物理康复领域的主要目标之一。为了实现这一目标,已经开发出一种系统来监测患者的负重表现,并提供音频反馈,以影响患者在手杖上的重量应用。智能手杖被设计为读取力测量值,比较读出的力,并在患者施加的力不正确时生成警报消息。该系统包括一个图形用户界面,允许实时绘制力测量图,并保留一个数据库,供治疗师离线比较数据分析。它使用蓝牙技术在微控制器和计算机之间进行无线连接,从而增加了患者的移动性。这将有助于患者获得最佳的康复,从而改善行走平衡并最终实现手杖独立。
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引用次数: 14
A pulse oximetry system with motion artifact reduction based on Fourier analysis 基于傅立叶分析的运动伪影抑制脉搏血氧测量系统
Yi-Hsiang Yang, K. Tang
In this paper, a system that records photoplethysmography and performs motion artifact reduction is proposed. In order to calculate SpO2, accurate amplitude of PPG is essential. As a matter of fact that the PPG signal is acquired through an optical sensor, it is prone to be affected by motion artifact. As a result, noise cancellation is a major issue in the calculation of SpO2. In the calculation of SpO2, the exact waveform is not the key point, whereas the amplitude plays the important role. Therefore, Fourier analysis is adopted to perform the noise cancellation. In the proposed system, data acquisition and analog filtering are done on a printed circuit board which is controlled by an FPGA. The acquired data are sent to a computer, where Fourier analysis is done to cancel motion artifact. Experiments have been done to demonstrate the performance of the proposed algorithm. The proposed system performs PPG signal acquisition, motion artifact reduction and SpO2 calculation.
本文提出了一种记录光体积脉搏波并进行运动伪影还原的系统。为了计算SpO2,精确的PPG振幅是必不可少的。事实上,PPG信号是通过光学传感器获取的,它很容易受到运动伪影的影响。因此,噪声消除是SpO2计算中的一个主要问题。在SpO2的计算中,精确的波形不是关键,振幅起着重要的作用。因此,采用傅里叶分析进行噪声消除。在该系统中,数据采集和模拟滤波是在由FPGA控制的印刷电路板上完成的。采集到的数据被发送到计算机,在那里进行傅里叶分析以消除运动伪影。实验证明了该算法的有效性。该系统实现了PPG信号采集、运动伪影减少和SpO2计算。
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引用次数: 6
An approach for estimation of the surface area of scalp flap based on the characteristic parameters after decompressive craniectomy 一种基于颅骨减压术后特征参数估计头皮皮瓣表面积的方法
Lian Gao, Ninghui Zhao, Jinxi Zhao, Qinhu Zhang, Lan-juan Liu, Yufeng Zhang, He Sun, Xinling Shi
An approach for the estimation of the surface area of scalp flap after decompressive craniectomy is presented in this paper to avoid the complications after cranioplasty since the area of the implanted prosthesis such as the titanium alloy is large than the surface area of the scalp flap. The estimation is based on the simulation model of skull with the characteristic parameters obtained from clinical statistics by using Mimics and the integration method to calculate the surface area of the scalp flap where the bone flap was removed for the relief of intractable intracranial hypertension in patients with severe traumatic brain injury by considering the sunken degree of the brain and scalp flap. In order to evaluate the performance of the proposed method, the comparison of the results obtained from the clinical statistical and simulation study is carried out. The results indicate that the computed value of the scalp flap area obtained from the simulation is consistent quite well with the results of clinical statistics.
为了避免颅骨成形术后由于植入的钛合金等假体面积大于头皮瓣表面积而导致的并发症,本文提出了一种估计颅骨减压切除术后头皮瓣表面积的方法。该估计是基于模拟颅骨模型,结合临床统计得到的特征参数,利用Mimics和积分法,考虑脑和头皮瓣的凹陷程度,计算重型颅脑损伤患者解除顽固性颅内高压时取骨瓣处的头皮瓣表面积。为了评价所提方法的性能,将临床统计和仿真研究结果进行了比较。结果表明,模拟得到的头皮皮瓣面积计算值与临床统计结果吻合较好。
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引用次数: 1
Analyzing spike I wave electroencephalogram signals for epilepsy based on Hilbert-Huang transformation 基于Hilbert-Huang变换的癫痫峰波脑电图信号分析
Jin-De Zhu, Chin-Feng Lin
In this paper, we use the Hilbert-Huang transform (HHT) analysis method to explore the time-frequency characteristics of spike waves for epilepsy symptoms. We obtained a sample of spike I wave and non-spike waves for HHT decomposition using a number of intrinsic mode functions of the Hilbert transform (HT) to determine the instantaneous spectrum, marginal spectrum, and Hilbert energy spectrum. We decomposed a number of intrinsic mode functions, the instantaneous spectrum and the Hilbert energy spectrum and compared the differences between spike and non-spike waves. The analysis results showed that the ratios of the normal wave to the referred total energy for IMF1, IMF2, and the residual function exceeded 10%. Furthermore, the ratios of the energy of the energy for IMF1, IMF2, IMF3 and the residual function of Spike I to their total energy also exceeded 10%. The ratios of the energy of IMF3 in the d band to its referred total energy for the EEG signal without spike wave, and of Spike I waves were 4.72%, and 6.75%, respectively. The ratios of the energy of IMF3 in the d band to its referred total energy for the EEG signal without spike wave is lower than that of the energy of IMF3 in the ν band to its referred total energy for the spike I wave.
本文采用Hilbert-Huang变换(HHT)分析方法探讨癫痫症状的尖峰波时频特征。利用希尔伯特变换(HT)的一些本征模态函数确定瞬时谱、边际谱和希尔伯特能谱,获得了尖峰I波和非尖峰波的HHT分解样本。我们分解了一些本征模态函数、瞬时谱和希尔伯特能谱,并比较了尖峰波和非尖峰波的差异。分析结果表明,IMF1、IMF2和残差函数的法向波占参考总能量的比例均超过10%。此外,IMF1、IMF2、IMF3和Spike I残余函数的能量占总能量的比例也超过10%。无尖峰波和尖峰波的脑电信号中,d波段的IMF3能量与参考总能量之比分别为4.72%和6.75%。对于无尖峰波的脑电图信号,IMF3在d波段的能量与参考总能量的比值小于IMF3在ν波段的能量与参考总能量的比值。
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引用次数: 1
期刊
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)
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