Michelia Champaca: Wound Healing Activity In Immunosuppressed Rats

Abstract

Objectives: To evaluate wound healing profile of alcoholic extract of Michelia champaca in different wound models in rats and to study its effect on Dexamethasone suppressed wound healing.Materials and methods: For assessment of wound healing activity, excision, incision and dead space wound models were used. Group I was assigned as control, Group II received alcoholic extract of M. champaca orally. Group III received Dexamethasone intra muscularly (i.m) and Group IV was given Dexamethasone i.m and alcoholic extract of M.champaca orally. Parameters observed were breaking strength of incision wound; epithelization and wound contraction in excision model and breaking strength, dry weight and hydroxyproline content in dead space wound model.Results: In incision model, it was noted that on co-administration of Dexamethasone and M.champaca the breaking strength was significantly increased. In dead space wound model, the hydroxyproline content was significantly increased in Dexamethasone + M.champaca treated group.Conclusion: It is concluded that M.champaca is an effective agent for healing of wounds in immunocompromised patients.