Hepatoprotective Potential of Caesalpinia bonducella: Molecular Insight

Abstract

Abstract: Liver fibrosis is a wound healing process initiated in response to chronic liver damage caused by viruses, toxins, and hepatotoxic drugs. The disease is characterized by inflammation followed by deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) has been identified as a host cofactor for hepatitis C virus (HCV) entry. The plant Caesalpinia bonducella is used in a variety of systems a traditional medicine used to treat human ailments and affiliation prickly shrub belonging to the Caesalpiniaceae family found throughout the world, especially tropical region. It is a very valuable medicinal plant because all parts of the plant have medicinal properties. It was like traditional Indian herbal medicine considered an important therapeutic modality for the treatment of various diseases. As per literature survey the plants containing kaempferol and quercetin-3-methylether are traditionally utilized for the cure of cancer and liver related disorders from the immortal time. The exact mechanism of action for the hepatoprotective action of kaempferol and quercetin-3-methylether was still not revealed. With intent to propose the most probable mechanism of action of kaempferol and quercetin-3-methylether the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.