Alpha Lipoic Acid (Ala) Combining with Corticosteroid Hormone Improves the Outcome of Infectious Diseases in Spinal Cord (10 Cases Study)

Xin Wang, A. Hubbard, G. Tan
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Abstract

Myelitis, Neuromylitis Optica (NMO) and Multiple Sclerosis (MS) are clinic common infectious diseases in spinal cord that are costly, progressive and often cause life-time disabilities. Methylprednisolone Sodium Succinate, a corticosteroid hormone, is a routine effective therapeutic drug for center nerve system (CNS) inflammation, especially applied for MS attacks [1]. However, long term and/or high dose use of corticosteroid hormone has serious side effects such as osteonecrosis of femoral head, cerebral hemorrhage, unstable blood pressure and blood sugar, disorder of kidney [2]. Therefore, corticosteroid hormone therapy is limited on clinical application.
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α硫辛酸联合皮质类固醇激素改善脊髓感染性疾病预后(附10例研究)
脊髓炎,视神经脊髓炎(NMO)和多发性硬化症(MS)是临床上常见的脊髓感染性疾病,费用昂贵,进行性且常导致终身残疾。甲泼尼龙琥珀酸钠是一种皮质类固醇激素,是治疗中枢神经系统炎症的常规有效药物,尤其适用于多发性硬化症发作[1]。然而,长期和/或大剂量使用皮质类固醇激素会产生严重的副作用,如股骨头坏死、脑出血、血压和血糖不稳定、肾脏紊乱等[2]。因此,皮质类固醇激素治疗在临床应用上受到限制。
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