THE INFLUENCE OF SYNBIOTICS ON PERIPHERAL BLOOD LEUKOCYTE OXIDATIVE BURST IN PATIENTS WITH ALLERGIC DISEASES

Abstract

Modulation of the gut microbiota with probiotics, living microorganisms with immunomodulatory effects, or prebiotics, nondigestible food ingredients that promote the growth and/or activity of beneficial microorganisms or a combination of both (synbiotics) may enable a new way of prevention or treatment for allergic disease. The aim of our study was to evaluate the ROS release from the peripheral blood neutrophils in patients with type I hypersensitivity reactions. To this end, we evaluated the basophil degranulation in the presence of specific allergens and analysed the influence of a synbiotic on neutrophil reactive oxygen species (ROS) generation. The tested synbiotic, directly or in combination with E. coli, decreased the ROS production in peripheral blood neutrophils of allergic patients. Taking into account that intensive ROS release is responsible for various damages of cells and tissues, the decrease of the oxidative stress induced by the tested synbiotic may have an essential role for cell protection and viability. Therefore, therapeutic interventions that enhance endogenous antioxidant defenses might be beneficial as adjunctive therapies for allergic disorders.