A framework for semantic segmentation of pathological tissue slices

Hongyan Liu
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Abstract

The study of cell nuclei is the starting point of pathological analysis and new drug development in modern medicine [1], and nuclear segmentation is a primary task of nuclear research. This paper proposes an optimization method for nuclear segmentation. It regards the Conditional Generative Adversarial Network (CGAN) [2] as the fundamental segmentation structure, segments the nuclear images by using deep learning Convolutional Neural Network (CNN) [3], and then optimizes and improves the generator, discriminator, and objective function. The experimental results demonstrate that the improved UGAN has superior performance on the semantic segmentation task of the images of pathological tissue slices and can be used as a tool for automatic segmentation of pathological tissue sections.
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病理组织切片语义分割框架
细胞核的研究是现代医学病理分析和新药开发的起点[1],细胞核分割是核研究的首要任务。提出了一种核分割的优化方法。它以条件生成对抗网络(Conditional Generative Adversarial Network, CGAN)[2]作为基本分割结构,利用深度学习卷积神经网络(Convolutional Neural Network, CNN)[3]对核图像进行分割,然后对生成器、鉴别器和目标函数进行优化和改进。实验结果表明,改进后的UGAN算法在病理组织切片图像的语义分割任务上具有优异的性能,可以作为病理组织切片自动分割的工具。
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