{"title":"Hemozoin: a Biocrystal Synthesized during the Degradation of Hemoglobin","authors":"D. Sullivan","doi":"10.1002/3527600035.BPOL9007","DOIUrl":null,"url":null,"abstract":"Introduction \nMalaria \nMalaria Pathogenesis \nHemoglobin Degradation \n \n \nHistorical Outline \nPigment Associates with Malaria \nPigment Links Mosquito to Plasmodium Life Cycle \n \n \nChemical Structure \nOccurrence \nFunction of Hemozoin \nStructure of Hemozoin \nAnalysis of Early Purifications \nComparison with Schistosomal Pigment \nHemozoin Lacks Protein \nThe Iron–Oxygen Coordinate Bond \nParamagnetic Hemozoin \n \n \nBiochemical Formation of Hemozoin \nFormalin Pigment \nOther Parasite Pigments \nPlasmodium Protein Initiation of Pigment \n \n \nInhibition of Hemozoin Formation \nImmune Modulation of Hemozoin \nPerturbation of Leukocyte Function \nLeukocyte Pigment as a Prognostic Indicator \n \n \nPatents \nOutlook and Perspectives \n \n \nKeywords: \n \nHeme; \niron; \nprotoporphyrin IX. Plasmodium falciparum; \nmalarial pigment; \nhemozoin; \nquinoline; \nchemotherapy; \nβ-hematin; \nheme polymer; \nSchistosoma; \nHaemoproteus; \nmalaria; \nimmunity; \nformalin pigment","PeriodicalId":165163,"journal":{"name":"Biopolymers Online","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2002-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"40","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/3527600035.BPOL9007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 40
Abstract
Introduction
Malaria
Malaria Pathogenesis
Hemoglobin Degradation
Historical Outline
Pigment Associates with Malaria
Pigment Links Mosquito to Plasmodium Life Cycle
Chemical Structure
Occurrence
Function of Hemozoin
Structure of Hemozoin
Analysis of Early Purifications
Comparison with Schistosomal Pigment
Hemozoin Lacks Protein
The Iron–Oxygen Coordinate Bond
Paramagnetic Hemozoin
Biochemical Formation of Hemozoin
Formalin Pigment
Other Parasite Pigments
Plasmodium Protein Initiation of Pigment
Inhibition of Hemozoin Formation
Immune Modulation of Hemozoin
Perturbation of Leukocyte Function
Leukocyte Pigment as a Prognostic Indicator
Patents
Outlook and Perspectives
Keywords:
Heme;
iron;
protoporphyrin IX. Plasmodium falciparum;
malarial pigment;
hemozoin;
quinoline;
chemotherapy;
β-hematin;
heme polymer;
Schistosoma;
Haemoproteus;
malaria;
immunity;
formalin pigment
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