Furan and thiophene analogues of omeprazole.

Acta pharmaceutica Nordica Pub Date : 1992-01-01
G Sorba, A Di Stilo, M Gili, A Gasco, G Bertaccini, M Adami, G Coruzzi
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Abstract

Synthesis and structure of some analogs of the omeprazole containing furan and thiophene rings are reported. Their effects on the basal and the histamine-stimulated secretion were evaluated on the isolated rat stomach.

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奥美拉唑的呋喃和噻吩类似物。
报道了几种含呋喃和噻吩环的奥美拉唑类似物的合成及其结构。在离体大鼠胃中评价了它们对基础和组胺刺激分泌的影响。
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Model systems in iontophoresis--transport efficacy. Furan and thiophene analogues of omeprazole. Chemical stability of insulin. 4. Mechanisms and kinetics of chemical transformations in pharmaceutical formulation. Chemical stability of insulin. 5. Isolation, characterization and identification of insulin transformation products. Relative bioavailability in man of noscapine administered in lozenges and mixture.
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