{"title":"Comparison of GLC-EMIT analysis for the assay of methadone and its major metabolite in urine","authors":"S.D. Ferrara, L. Tedeschi, F. Castagna, M. Marigo","doi":"10.1016/0379-0738(78)90117-2","DOIUrl":null,"url":null,"abstract":"<div><p>The enzyme-multiplied immunoassay technique (EMIT) was compared with the gas-liquid chromatographic (GLC) method in the analysis of 130 urine samples from subjects receiving methadone treatment and non-methadone controls. The GC method allowed the quantitation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, the major metabolite of methadone. A good correlation was found between the two methods. The advantages of using the EMIT system are discussed.</p></div>","PeriodicalId":75860,"journal":{"name":"Forensic science","volume":"11 1","pages":"Pages 181-188"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0379-0738(78)90117-2","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forensic science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0379073878901172","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
The enzyme-multiplied immunoassay technique (EMIT) was compared with the gas-liquid chromatographic (GLC) method in the analysis of 130 urine samples from subjects receiving methadone treatment and non-methadone controls. The GC method allowed the quantitation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, the major metabolite of methadone. A good correlation was found between the two methods. The advantages of using the EMIT system are discussed.
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