{"title":"Image analysis of gap junction structures","authors":"Gina E. Sosinsky","doi":"10.1016/0892-0354(92)90005-B","DOIUrl":null,"url":null,"abstract":"<div><p>Isolated gap junction plaques contain hexagonal crystalline arrays of membrane channels called connexons which are a suitable specimen for electron crystallography. Image analysis of gap junction lattices has shown that while there is sufficient lattice order for structural analysis to ∼25 Å, there is enough disorder in both the lattice and the connexon to create a family of related images. This review is focused on how these images can be interpreted in terms of what is known about both the connexon and its constituent protein, connexin.</p></div>","PeriodicalId":77112,"journal":{"name":"Electron microscopy reviews","volume":"5 1","pages":"Pages 59-76"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0892-0354(92)90005-B","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electron microscopy reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089203549290005B","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 25
Abstract
Isolated gap junction plaques contain hexagonal crystalline arrays of membrane channels called connexons which are a suitable specimen for electron crystallography. Image analysis of gap junction lattices has shown that while there is sufficient lattice order for structural analysis to ∼25 Å, there is enough disorder in both the lattice and the connexon to create a family of related images. This review is focused on how these images can be interpreted in terms of what is known about both the connexon and its constituent protein, connexin.
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