Intrahepatic Cholestasis of Pregnancy: Evaluation of Risk Factors and Predictive Factors.

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a low prevalence pathology associated with premature delivery and fetal death. Objective: To determine risk factors, clinical course and predictive factors in a cohort of ICP patients.Methods: A retrospective cohort study was performed. There were studied fifty patients with ICP and 51 healthy women. Results: ICP was more frequently found in multiparous, multiple pregnancies and ICP antecedent. Women with ICP had a greater incidence of premature delivery (76.0%, p=0.001). Meconium-stained amniotic fluid was more frequent in ICP women (p=0.002). The newborns showed differences in weight, size and gestational age, attributable to the difference in gestational age at birth. Conclusions: Advanced maternal age, multiparity, antecedent ICP and multiple pregnancies increase the risk of ICP. The consequences of ICP might be premature delivery and meconium-stained amniotic fluid at delivery