{"title":"The influence of normobaric hyperoxia on lung surfactant phospholipids in rats.","authors":"A Ledwozyw, B Borowicz","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The influence of 12-, 24- and 48-h normobaric hyperoxia on phospholipid composition of lung surfactant in rats was investigated. Both in surfactant isolated from bronchoalveolar lavage and in surfactant isolated from lung tissue after 12 h breathing of pure oxygen, a decrease in both phosphatidylcholine (particularly in disaturated ones) and phosphatidylglycerol content was observed. This decrease was compensated with concomitant increase in lysophosphoglyceride content. A drop in total phospholipid level in surfactant of oxygen-exposed rats was observed. These data suggest that normobaric hyperoxia causes a substantial changes in lung surfactant composition and type II pneumocyte metabolism.</p>","PeriodicalId":8381,"journal":{"name":"Archivum veterinarium Polonicum","volume":"32 3-4","pages":"127-33"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivum veterinarium Polonicum","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The influence of 12-, 24- and 48-h normobaric hyperoxia on phospholipid composition of lung surfactant in rats was investigated. Both in surfactant isolated from bronchoalveolar lavage and in surfactant isolated from lung tissue after 12 h breathing of pure oxygen, a decrease in both phosphatidylcholine (particularly in disaturated ones) and phosphatidylglycerol content was observed. This decrease was compensated with concomitant increase in lysophosphoglyceride content. A drop in total phospholipid level in surfactant of oxygen-exposed rats was observed. These data suggest that normobaric hyperoxia causes a substantial changes in lung surfactant composition and type II pneumocyte metabolism.
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