Research Progress on the Effect of Vitamin D on the Pathogenesis of Kawasaki Disease and the Prediction of Coronary Artery Lesion

Abstract

Kawasaki Disease (KD), also known as mucocutaneous lymph node syndrome, is a kind of fever rash pediatric disease with systemic vasculitis as the main lesion. Its pathogenesis is not yet completely clear, the main pathological changes is systemic vasculitis, involving the small and medium-sized blood vessels of the body, especially coronary artery lesions are more obvious, can lead to coronary artery aneurysm, even serious sudden death. Because the disease can appear serious cardiovascular complications, has gradually attracted attention, in recent years, its incidence has gradually increased trend, has become one of the common pediatric acquired heart disease etiology. Vitamin D acts on the VDR in various tissues and cells of the human body. Many studies have shown that vitamin D not only participates in the traditional calcium and phosphorus metabolism, but also participates in immune regulation through a variety of mechanisms.