Electroporation Modelling of Irregularly Nucleated Cell With Perinuclear Space

Abstract

Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non–linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye–based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.