Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9384899
Hana Mozerova, R. Scapaticci, J. Vrba, L. Crocco
In this paper, we present the initial results of a research work aimed at assessing the capabilities of microwave imaging as an effective tool for in-line monitoring of regional hyperthermia treatments. Based on the variation of the electromagnetic properties of tissue due the increase of temperature, it is possible to exploit the processing of the scattered fields gathered during the thermal treatment to track its evolution. The anatomical scenario is the pelvic region and the target of the thermal treatment is the bladder. The first challenge is to verify if and to what extent microwave signals may achieve a sufficient penetration and spatial resolution to pursue the desired task. Based on a simple theoretical analysis, the suitable frequency range and operating conditions are determined and some numerical simulations involving a 2D anthropomorphic phantom are provided to show the potential of microwave imaging to undertake this monitoring task.
{"title":"Monitoring regional hyperthermia via microwave imaging: a feasibility study","authors":"Hana Mozerova, R. Scapaticci, J. Vrba, L. Crocco","doi":"10.1109/IMBIoC47321.2020.9384899","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9384899","url":null,"abstract":"In this paper, we present the initial results of a research work aimed at assessing the capabilities of microwave imaging as an effective tool for in-line monitoring of regional hyperthermia treatments. Based on the variation of the electromagnetic properties of tissue due the increase of temperature, it is possible to exploit the processing of the scattered fields gathered during the thermal treatment to track its evolution. The anatomical scenario is the pelvic region and the target of the thermal treatment is the bladder. The first challenge is to verify if and to what extent microwave signals may achieve a sufficient penetration and spatial resolution to pursue the desired task. Based on a simple theoretical analysis, the suitable frequency range and operating conditions are determined and some numerical simulations involving a 2D anthropomorphic phantom are provided to show the potential of microwave imaging to undertake this monitoring task.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130413361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9384900
A. Nefzi, R. Orlacchio, Lynn Carr, N. Lewis, Y. Percherancier, P. Lévêque, D. Arnaud-Cormos
The precise characterization of electromagnetic fields exposure systems requires accurate dosimetry from macroscale down to the cellular level. In this study, two different exposure devices based on microelectrodes arrays for real-time cellular characterization, namely a Micro-Electrode Array (MEA) and an impedancemetry well with interdigitated electrodes were considered. For the first time, the heating induced by the exposure to radiofrequency in the electrodes vicinity was retrieved from the fluorescence intensity of Rhodamine B (Rhod-B), which linearly changes as a function of the temperature variation. Our results confirm that the use of Rhod-B represents a reliable technique to obtain temperature information at the microscopic scale.
{"title":"Microscale Temperature Measurements Within Specific Exposure Systems for Real-Time Cellular Characterization","authors":"A. Nefzi, R. Orlacchio, Lynn Carr, N. Lewis, Y. Percherancier, P. Lévêque, D. Arnaud-Cormos","doi":"10.1109/IMBIoC47321.2020.9384900","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9384900","url":null,"abstract":"The precise characterization of electromagnetic fields exposure systems requires accurate dosimetry from macroscale down to the cellular level. In this study, two different exposure devices based on microelectrodes arrays for real-time cellular characterization, namely a Micro-Electrode Array (MEA) and an impedancemetry well with interdigitated electrodes were considered. For the first time, the heating induced by the exposure to radiofrequency in the electrodes vicinity was retrieved from the fluorescence intensity of Rhodamine B (Rhod-B), which linearly changes as a function of the temperature variation. Our results confirm that the use of Rhod-B represents a reliable technique to obtain temperature information at the microscopic scale.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121699639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385044
S. Winkler, I. Saniour, Akshay Chaudhari, F. Robb, J. Vaughan
A to-date unsolved and highly limiting safety concern for Ultra High-Field (UHF) magnetic resonance imaging (MRI) is the deposition of radiofrequency (RF) power in the body, quantified by the specific absorption rate (SAR), leading to dangerous tissue heating/damage in the form of local SAR hotspots that cannot currently be measured/monitored, thereby severely limiting the applicability of the technology for clinical practice and in regulatory approval. The goal of this study has been to show proof of concept of an artificial intelligence (AI) based exam-integrated real-time MRI safety prediction software (MRSaiFE) facilitating the safe generation of 3T and 7T images by means of accurate local SAR-monitoring at sub-W/kg levels. We trained the software with a small database of image as a feasibility study and achieved successful proof of concept for both field strengths. SAR patterns were predicted with a residual root mean squared error (RSME) of < 11{%}$ along with a structural similarity (SSIM) level of > 84{%}$ for both field strengths (3T and 7T).
{"title":"MRSaiFE: Tissue Heating Prediction for MRI: a Feasibility Study","authors":"S. Winkler, I. Saniour, Akshay Chaudhari, F. Robb, J. Vaughan","doi":"10.1109/IMBIoC47321.2020.9385044","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385044","url":null,"abstract":"A to-date unsolved and highly limiting safety concern for Ultra High-Field (UHF) magnetic resonance imaging (MRI) is the deposition of radiofrequency (RF) power in the body, quantified by the specific absorption rate (SAR), leading to dangerous tissue heating/damage in the form of local SAR hotspots that cannot currently be measured/monitored, thereby severely limiting the applicability of the technology for clinical practice and in regulatory approval. The goal of this study has been to show proof of concept of an artificial intelligence (AI) based exam-integrated real-time MRI safety prediction software (MRSaiFE) facilitating the safe generation of 3T and 7T images by means of accurate local SAR-monitoring at sub-W/kg levels. We trained the software with a small database of image as a feasibility study and achieved successful proof of concept for both field strengths. SAR patterns were predicted with a residual root mean squared error (RSME) of < 11{%}$ along with a structural similarity (SSIM) level of > 84{%}$ for both field strengths (3T and 7T).","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121791520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9384907
P. Marín, Joanatan Borges, P. Gueye, M. Vélez
In recent years, much interest and effort have been devoted to develop soft magnetic materials due to their technological potential [1]. Amorphous microwires are one of the most widely studied soft materials. They are fabricated by means of extracting melt-spinning Taylor technique. Those microwires are composed by a metallic core and a Pyrex cover both in the micrometer range. The ratio between the total diameter and the magnetic core, often called aspect ratio, is one of the key parameters of such microwires, since magnetic properties depend dramatically on it. Many properties of these materials have been deeply studied both from the point of view of the basic physics and the applications. This is the case of the giant magnetoimpedance effect [2], bistability, ferromagnetic resonance [3], and magnetoelastic resonance [4]. It is easy, also, to find much literature regarding microwave-related applications of microwires or microwire-based materials [5]. In the frequency range of GHz, some experimental and theoretical studies of the effect of the magnetization on the scattering properties of a single microwire have been developed [6]. This kind of work gives experimental evidence showing that the microwave scattering by a single microwire depends on the magnetic permeability with sufficient strength to be experimentally detected as an effect of the GMI. This dependence was used to show the potential of such microwire as a wireless field and/or stress sensor. Experimental results are followed by a theoretical approach where the influence of the microwire magnetic state in its microwave reflection features is taken into account. Besides these investigations on magnetic microwires, it should be stated that technological development has spurred the growing interest in the investigation of new biosensors aimed at simplifying present day diagnostic methods and thereby improving medical care, so that it improves the quality of life of the patients and allows for outpatient treatment for a number of pathologies, avoiding unnecessary hospital admissions. Magnetic sensors are at the helm of technological development seen in this field over the last decades, offering numerous advantages attributed to their elevated sensitivity, reduced size, systems without the need for an external source of energy, and wireless connections. The use of wireless sensor network (WSN) technologies offers the possibility of developing implantable biomedical sensors allowing for the monitorization and follow-up of certain physiological parameters with precise and, up until now, unthinkable measurements. The aim of the present work is to show the physical fundamentals and the particular biomedical applications of magnetic microwires as wireless stress sensors. Two main applications will be described. On one side we proposed a flexible magnetic element able to be integrated both in artery and prosthesis suitable for wireless localized blood pressure monitoring. The sensor made of a
{"title":"Wireless Stress Sensor Based on Magnetoelastic Microwires for Biomedical Applications: detection of collagen concentration","authors":"P. Marín, Joanatan Borges, P. Gueye, M. Vélez","doi":"10.1109/IMBIoC47321.2020.9384907","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9384907","url":null,"abstract":"In recent years, much interest and effort have been devoted to develop soft magnetic materials due to their technological potential [1]. Amorphous microwires are one of the most widely studied soft materials. They are fabricated by means of extracting melt-spinning Taylor technique. Those microwires are composed by a metallic core and a Pyrex cover both in the micrometer range. The ratio between the total diameter and the magnetic core, often called aspect ratio, is one of the key parameters of such microwires, since magnetic properties depend dramatically on it. Many properties of these materials have been deeply studied both from the point of view of the basic physics and the applications. This is the case of the giant magnetoimpedance effect [2], bistability, ferromagnetic resonance [3], and magnetoelastic resonance [4]. It is easy, also, to find much literature regarding microwave-related applications of microwires or microwire-based materials [5]. In the frequency range of GHz, some experimental and theoretical studies of the effect of the magnetization on the scattering properties of a single microwire have been developed [6]. This kind of work gives experimental evidence showing that the microwave scattering by a single microwire depends on the magnetic permeability with sufficient strength to be experimentally detected as an effect of the GMI. This dependence was used to show the potential of such microwire as a wireless field and/or stress sensor. Experimental results are followed by a theoretical approach where the influence of the microwire magnetic state in its microwave reflection features is taken into account. Besides these investigations on magnetic microwires, it should be stated that technological development has spurred the growing interest in the investigation of new biosensors aimed at simplifying present day diagnostic methods and thereby improving medical care, so that it improves the quality of life of the patients and allows for outpatient treatment for a number of pathologies, avoiding unnecessary hospital admissions. Magnetic sensors are at the helm of technological development seen in this field over the last decades, offering numerous advantages attributed to their elevated sensitivity, reduced size, systems without the need for an external source of energy, and wireless connections. The use of wireless sensor network (WSN) technologies offers the possibility of developing implantable biomedical sensors allowing for the monitorization and follow-up of certain physiological parameters with precise and, up until now, unthinkable measurements. The aim of the present work is to show the physical fundamentals and the particular biomedical applications of magnetic microwires as wireless stress sensors. Two main applications will be described. On one side we proposed a flexible magnetic element able to be integrated both in artery and prosthesis suitable for wireless localized blood pressure monitoring. The sensor made of a ","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129830921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385054
Javad Ebrahimizadeh, Alireza Maananejad, S. Sadeghi, R. Karlsson, Bappaditya Mandal, P. Rangaiah, M. Pérez, R. Augustine
This paper presents the feasibility of using a microwave imaging system for monitoring bone mineralization progress overtime after craniotomy surgery. Any variation in the composition of the bone flap can be monitored as a variation in the intensity of the image. A simulation is conducted on a head structure derived from a numerical head phantom based on anatomically realistic MRI–derived FDTD models using commercial CST 2019 software. For simulation, a defect is provided in the skull layer surrounded by a 9–elements antenna. Applying Space-Frequency Time Reversal (TR) method, the image of defect is constructed for different permittivity of the defect ranging from 16 to 36. Results show that the image intensity at the defect location will decrease as the permittivity of the defect decreases.
{"title":"Time Reversal Microwave Imaging of Realistic Numerical Head Phantom for Bone Flap Healing Follow-up","authors":"Javad Ebrahimizadeh, Alireza Maananejad, S. Sadeghi, R. Karlsson, Bappaditya Mandal, P. Rangaiah, M. Pérez, R. Augustine","doi":"10.1109/IMBIoC47321.2020.9385054","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385054","url":null,"abstract":"This paper presents the feasibility of using a microwave imaging system for monitoring bone mineralization progress overtime after craniotomy surgery. Any variation in the composition of the bone flap can be monitored as a variation in the intensity of the image. A simulation is conducted on a head structure derived from a numerical head phantom based on anatomically realistic MRI–derived FDTD models using commercial CST 2019 software. For simulation, a defect is provided in the skull layer surrounded by a 9–elements antenna. Applying Space-Frequency Time Reversal (TR) method, the image of defect is constructed for different permittivity of the defect ranging from 16 to 36. Results show that the image intensity at the defect location will decrease as the permittivity of the defect decreases.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127910086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385028
F. Snigdha, S. M. Islam, O. Boric-Lubecke, V. Lubecke
In-home sleep monitoring system using Microwave Doppler radar is gaining attention as it is unobtrusive and noncontact form of measurement. Most of the reported results in literature focused on utilizing radar-reflected signal amplitude to recognize Obstructive sleep apnea (OSA) events which requires iterative analysis and cannot recommend about sleep positions also (supine, prone and side). In this paper, we propose a new, robust and automated ERCS-based (Effective Radar Cross section) method for classifying OSA events (normal, apnea and hypopnea) by integrating radar system in a clinical setup. In our prior attempt, ERCS has been proven versatile method to recognize different sleep postures. We also employed two different machine learning classifiers (K-nearest neighbor (KNN) and Support Vector machine (SVM) to recognize OSA events from radar captured ERCS and breathing rate measurement from five different patients' clinical study. SVM with quadratic kernel outperformed with other classifiers with an accuracy of 96.7 % for recognizing different OSA events. The proposed system has several potential applications in healthcare, continuous monitoring and security/surveillance applications.
{"title":"Obstructive Sleep Apnea (OSA) Events Classification by Effective Radar Cross Section (ERCS) Method Using Microwave Doppler Radar and Machine Learning Classifier","authors":"F. Snigdha, S. M. Islam, O. Boric-Lubecke, V. Lubecke","doi":"10.1109/IMBIoC47321.2020.9385028","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385028","url":null,"abstract":"In-home sleep monitoring system using Microwave Doppler radar is gaining attention as it is unobtrusive and noncontact form of measurement. Most of the reported results in literature focused on utilizing radar-reflected signal amplitude to recognize Obstructive sleep apnea (OSA) events which requires iterative analysis and cannot recommend about sleep positions also (supine, prone and side). In this paper, we propose a new, robust and automated ERCS-based (Effective Radar Cross section) method for classifying OSA events (normal, apnea and hypopnea) by integrating radar system in a clinical setup. In our prior attempt, ERCS has been proven versatile method to recognize different sleep postures. We also employed two different machine learning classifiers (K-nearest neighbor (KNN) and Support Vector machine (SVM) to recognize OSA events from radar captured ERCS and breathing rate measurement from five different patients' clinical study. SVM with quadratic kernel outperformed with other classifiers with an accuracy of 96.7 % for recognizing different OSA events. The proposed system has several potential applications in healthcare, continuous monitoring and security/surveillance applications.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134281652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385050
Maréva Calvet-Chautard, Patricio Felipe Jaque Gonzalez, T. Véronèse, D. Dubuc, K. Grenier
This paper presents a microwave sensor designed to dielectrically characterize tissues of animal origin (duck in our case) in the frequency range of 0.1 to 6 GHz for meat freshness evaluation. This contact sensor is used as a transmit-and-receive sensor. Its validity is firstly verified with reference liquids. A dielectric characterization is then performed on a duck breast at different maturation days. In each case, repeatability of the measurements was checked. The obtained dielectric response of the duck breast changes over time. This result enables the future use of the sensor and the measurement technique in various applications and for the agroindustry notably for the monitoring of the meat freshness.
{"title":"Microwave-Based Sensor Dedicated to the Characterization of Meat Freshness","authors":"Maréva Calvet-Chautard, Patricio Felipe Jaque Gonzalez, T. Véronèse, D. Dubuc, K. Grenier","doi":"10.1109/IMBIoC47321.2020.9385050","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385050","url":null,"abstract":"This paper presents a microwave sensor designed to dielectrically characterize tissues of animal origin (duck in our case) in the frequency range of 0.1 to 6 GHz for meat freshness evaluation. This contact sensor is used as a transmit-and-receive sensor. Its validity is firstly verified with reference liquids. A dielectric characterization is then performed on a duck breast at different maturation days. In each case, repeatability of the measurements was checked. The obtained dielectric response of the duck breast changes over time. This result enables the future use of the sensor and the measurement technique in various applications and for the agroindustry notably for the monitoring of the meat freshness.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115394198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385048
Arda Secme, H. S. Pisheh, H. Uslu, Ozge Akbulut, R. T. Erdogan, M. Hanay
The size of a cell is one of the most fundamental biophysical parameters it possesses. Traditionally size measurements are done by using optical microscopy and quantitative phase imaging. However, a sensor with higher resolution, high throughput and lower cost is still needed. Here, a novel microfluidics-integratedmicrowave sensor is demonstrated to characterize single cells in real-time without labelling. Coplanar waveguide resonator is designed with a bowtie-shaped sensing electrodes separated by $50 mu mathrm{m}$. Cells are transported to sensing region by microfluidic channels and their sizes are measured simultaneously by the microwave sensors and optical microscopy. To enhance the microwave resolution, the microwave resonator is equipped with external heterodyne measurement circuitry detecting each and every cell passing through the sensing region. By comparing quantitative microscopic image analysis with frequency shifts, we show that microwave sensors can effectively measure cellular size. Our results indicate that microfluidics-integrated microwave sensors (MIMS) can be used for detecting.
细胞的大小是它所拥有的最基本的生物物理参数之一。传统的尺寸测量是通过光学显微镜和定量相位成像来完成的。但是，仍然需要一种高分辨率、高吞吐量和低成本的传感器。在这里，一种新型的微流体集成微波传感器被证明可以实时表征单细胞而无需标记。共面波导谐振器采用领结形感应电极，电极间距为$50 mu mathm {m}$。通过微流控通道将细胞输送到传感区域，利用微波传感器和光学显微镜同时测量细胞的大小。为了提高微波分辨率，在微波谐振腔内配置外差测量电路，对通过感应区的每个细胞进行检测。通过与频移的定量显微图像分析比较，我们证明微波传感器可以有效地测量细胞大小。结果表明，微流控集成微波传感器(MIMS)可以用于检测。
{"title":"Microfluidics-Integrated Microwave Sensors for Single Cells Size Discrimination","authors":"Arda Secme, H. S. Pisheh, H. Uslu, Ozge Akbulut, R. T. Erdogan, M. Hanay","doi":"10.1109/IMBIoC47321.2020.9385048","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385048","url":null,"abstract":"The size of a cell is one of the most fundamental biophysical parameters it possesses. Traditionally size measurements are done by using optical microscopy and quantitative phase imaging. However, a sensor with higher resolution, high throughput and lower cost is still needed. Here, a novel microfluidics-integratedmicrowave sensor is demonstrated to characterize single cells in real-time without labelling. Coplanar waveguide resonator is designed with a bowtie-shaped sensing electrodes separated by $50 mu mathrm{m}$. Cells are transported to sensing region by microfluidic channels and their sizes are measured simultaneously by the microwave sensors and optical microscopy. To enhance the microwave resolution, the microwave resonator is equipped with external heterodyne measurement circuitry detecting each and every cell passing through the sensing region. By comparing quantitative microscopic image analysis with frequency shifts, we show that microwave sensors can effectively measure cellular size. Our results indicate that microfluidics-integrated microwave sensors (MIMS) can be used for detecting.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124957800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.1109/IMBIoC47321.2020.9385019
Lena Kranold, Muberra Ozmen, M. Coates, M. Popovic
We here report on a protocol of system performance for the microwave radar breast health monitoring prototype. The device aims to detect breast cancer at an early stage and operates in the multistatic mode with 16 transceiving antennas. After introducing hardware changes, we developed a system performance protocol to repeatably test our system in preparation for clinical trials. It includes repeated scans using breast phantoms, and we investigated if the phantoms can be used without a matching medium not only with an ideally-fitting antenna housing, but also with the prosthetic bra used in clinical trials. We compare the system performance with both antenna housing options and introduce a system performance protocol for the clinical trials.
{"title":"Microwave Radar for Breast Health Monitoring: System Performance Protocol","authors":"Lena Kranold, Muberra Ozmen, M. Coates, M. Popovic","doi":"10.1109/IMBIoC47321.2020.9385019","DOIUrl":"https://doi.org/10.1109/IMBIoC47321.2020.9385019","url":null,"abstract":"We here report on a protocol of system performance for the microwave radar breast health monitoring prototype. The device aims to detect breast cancer at an early stage and operates in the multistatic mode with 16 transceiving antennas. After introducing hardware changes, we developed a system performance protocol to repeatably test our system in preparation for clinical trials. It includes repeated scans using breast phantoms, and we investigated if the phantoms can be used without a matching medium not only with an ideally-fitting antenna housing, but also with the prosthetic bra used in clinical trials. We compare the system performance with both antenna housing options and introduce a system performance protocol for the clinical trials.","PeriodicalId":297049,"journal":{"name":"2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124420036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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