Evaluating the Impact of Alcohol Control Interventions on Suicide Mortality Rates

Xinyang Feng, Huan Jiang
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Abstract

Introduction & Objective: Given that the impact of regulatory and public policy initiatives cannot usually be tested through traditional randomized controlled trial designs, well-selected, -designed, and -analyzed natural experiments are the method of choice when examining the effects of such enactments on a variety of outcomes. The classic methodology for such evaluations is interrupted time-series (ITS) analysis, which is considered as one of the quasi-experimental designs that use both pre- and post-policy data without randomization. This study tests the impact of alcohol control interventions implemented in different period of times on suicide mortality rates among people 25-74 years of age using ITS. Methods: We mainly use the generalized additive mixed model (GAMM) to capture trend and seasonality in suicide mortality rates while controlling for unemployment rates, financial crisis during 2007-2008, and legal alcohol consumption records. Given the notable differences in alcohol consumption and suicide mortality between males and females, all analyses are conducted gender-specifically. Results: The ITS shows that the intervention introduced in 2017 has a significant effect on reducing suicide mortality rates for males between 25 and 74. Following the implementation of the intervention, suicide mortality rates decreased by 23.8% (95% CI: 10.2% - 35.4%) on average. Conclusion: The alcohol control intervention that strictly increased the excise tax on alcohol products has been shown to have a strong impact on reducing suicide mortality rates among male adults 25-74 years of age. ITS analyses are one of the strongest evaluative designs and allow a more detailed assessment of the longitudinal impact of an intervention than may be possible with a randomized control trial.
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评估酒精控制干预措施对自杀死亡率的影响
引言与目标:鉴于监管和公共政策举措的影响通常不能通过传统的随机对照试验设计来测试,因此,在检查此类颁布对各种结果的影响时,精心选择,设计和分析的自然实验是首选方法。这种评估的经典方法是中断时间序列(ITS)分析,它被认为是一种准实验设计,同时使用政策前和政策后的数据,没有随机化。本研究测试了不同时期实施的酒精控制干预措施对使用ITS的25-74岁人群自杀死亡率的影响。方法:在控制失业率、2007-2008年金融危机和合法饮酒记录的情况下,主要采用广义加性混合模型(GAMM)捕捉自杀死亡率的趋势和季节性。鉴于男性和女性在饮酒量和自杀死亡率方面的显著差异,所有分析都是针对性别进行的。结果:ITS显示,2017年引入的干预措施对降低25 - 74岁男性自杀死亡率有显著效果。实施干预后,自杀死亡率平均下降23.8%(95%置信区间:10.2% - 35.4%)。结论:严格提高酒精产品消费税的酒精控制干预措施已被证明对降低25-74岁男性成年人的自杀死亡率有很大影响。ITS分析是最强的评价设计之一,与随机对照试验相比,它允许对干预措施的纵向影响进行更详细的评估。
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