Correlation of Hepatic Steatosis with Hepatic Fibrosis in NAFLD Patients by Fibroscan

R. Sehgal, Jyotisterna Mittal, I. Singh
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引用次数: 1

Abstract

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a significant cause of liver injury in the world. Transient elastography with controlled attenuation parameter (CAP) is now days commonly used as a non-invasive modality to quantify liver steatosis and stage of Fibrosis in the Liver. This study was done to the correlation of hepatic Steatosis with hepatic Fibrosis in NAFLD Patients by fibroscan. Subjects and Methods: All NAFLD patients coming to DMCH from 1/1/18 to 30/11/18 were retrospectively analysed for the presence of any correlation between Steatosis and Fibrosis using a controlled attenuation parameter (CAP) and liver stiffness measurement (kPa), respectively by Fibroscan. Patients with a history of significant alcohol intake, viral infection, severe weight loss, on TPN, on drugs like amiodarone, diltiazem, steroids were excluded. Along with this history of hypertension, diabetes and smoking were noted from the available data. Results: The mean CAP of all 446 patients was 310.58  53.55 and the mean kPa was 7.14   4.75. Overall there was a significant correlation between CAP and kPa in all NAFLD patients (p <0.000). This was also true in patients who were more than 20 years of age, who have increased levels of triglycerides and were obese. Patients with S0 steatosis had a mean kPa value of 5.33 and as the steatosis stage worsened to S3 mean kPa value also increased to a maximum of 7.63. Conclusion: Quantification of Steatosis by CAP has a significant correlation with the stage of Fibrosis, especially in patients with increasing age, obese and who have high triglyceride levels.
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NAFLD患者肝脂肪变性与肝纤维化的相关性
简介:非酒精性脂肪性肝病(NAFLD)是世界范围内肝损伤的重要原因。瞬时弹性成像控制衰减参数(CAP)是目前常用的一种非侵入性方法来量化肝脂肪变性和肝纤维化分期。本研究通过纤维扫描对NAFLD患者肝脂肪变性与肝纤维化的相关性进行了研究。对象和方法:从1/1/18到30/11/18到DMCH的所有NAFLD患者分别使用纤维扫描控制衰减参数(CAP)和肝脏硬度测量(kPa)回顾性分析脂肪变性和纤维化之间是否存在任何相关性。排除有严重酒精摄入史、病毒感染史、严重体重减轻史、TPN史、胺碘酮史、地尔硫卓史、类固醇史的患者。除了高血压病史外,还有糖尿病和吸烟病史。结果:446例患者CAP平均值为310.58 53.55,kPa平均值为7.14 4.75。总的来说,所有NAFLD患者CAP和kPa之间存在显著相关性(p <0.000)。20岁以上、甘油三酯水平升高、肥胖的患者也是如此。S0期脂肪变性患者的平均kPa值为5.33,随着脂肪变性恶化到S3期,平均kPa值也增加到最大值7.63。结论:CAP定量脂肪变性与纤维化分期有显著相关性,特别是在年龄增长、肥胖和甘油三酯水平高的患者中。
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