Effects of arterial insufficiency on glucose uptake by fast and slow rat skeletal muscles.

Abstract

1. Muscle wet weight and glucose uptake were measured in female Wistar rats 7 and 14 days after unilateral ligation and section of the artery. 2. Following the induction of arterial insufficiency, muscle wet weight decreased significantly in the extensor digitorum longus (EDL), but not in the soleus muscle (Sol). 3. Muscle glucose uptake per wet weight increased significantly in EDL after arterial insufficiency, but not in Sol. 4. It is suggested that arterial insufficiency influences the metabolic control of fast muscle via anoxia as a main etiologic factor.