Strong Expression of Fc-Receptors on Leukemic Cells in Hairy Cell Leukemia

Abstract

The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fe-receptor activity on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of ¹²⁵I-labelled aggregated IgG under saturation conditions, it was found that the hairy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound ¹²⁵I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4°C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20°C.