Electron-microscopic studies on the effect of calcium pantothenate upon rat liver and locally irradiated epidermis.

Abstract

Calcium pantothenate was administered to Wistar rats in a dose of 180 mg/day/rat for 42 days, in order to investigate its effect upon the ultrastructure of the epidermis locally irradiated with a dose of 600 rep and upon partly hepatectomized liver and locally irradiated epidermis, as compared to control. The resulting data have revealed that calcium pantothenate is metabolized without entailing ultrastructural changes. Both liver and epidermis appear to be protected by calcium pantothenate, which greatly diminishes or even cancels the display of irradiation-induced negative effects. The changes brought about by irradiation are throughly presented and the subcellular mechanisms providing the radioprotection of epidermis and liver are accurately defined.