Ensemble algorithms for DNA motif finding

Abstract

Understanding the regulation of gene expression is one of the major research problems in biology. An important part of this problem is to identify the binding sites in DNA for transcription factors. These binding sites are called motifs. The performance of de novo motif discovery algorithms is limited. To address the issue, ensemble methods have been proposed in order to enhance the prediction accuracy by exploiting the information obtained from multiple algorithms. This paper reviews the latest developments of integrated algorithms in DNA motif finding.