The novel drug delivery systems in liver dysfunction

Abstract

The liver is a vital organ present in vertebrates and some other animals. Its wide functions include detoxification, protein synthesis, and production of biochemical necessary for digestion. This organ is necessary for survival. Currently there is no option to compensate for the absence of liver function. Drug targeting for various liver diseases can focus on various cells of liver including kupffer cells, sinusoidal endothelial cells, hepatic stellate cells or hepatocytes. In one or the other diseases, the involvement of these diseases has been clarified. Several diseases afflict liver. The major diseases of liver include HBV infection, liver fibrosis/cirrhosis, hepatocellular cancer. Several cells of the liver which are exposed to blood circulation or not exposed to blood circulation are involved in these diseases. Although conventional routes of administration can lead to drug access into these varieties of cells, means to increase the effectiveness of these by various drug delivery approaches has been attempted recently. This review briefly covers the latest and retrospective drug delivery system approaches published in the scientific literature.