Effect of Docosahexaenoic Acid supplementation on Microbiota in Obese ChiLdrEn: a pilot study. (The DAMOCLE study).

Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease Pub Date : 2020-10-30 DOI:10.3390/iecn2020-07012

E. Verduci, Matilde Amatruda, S. Vizzuso, V. Fabiano, E. Borghi, G. Zuccotti

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引用次数: 1

Abstract

: Introduction: Obesity is an inflammatory condition associated with metabolic alterations. Recent researches suggested that gut microbiota plays a role in its pathogenesis, as obesity has been associated with lower bacterial diversity and higher Firmicutes/Bacteroidetes ratio (F/R ratio) compared to normal‐weight condition. Such alterations can affect metabolite production (mainly short-chain fatty acids) having an impact on inflammatory markers modulation and insulin secretion. Objectives and study : To determine the effect of 4 months 500 mg/day DHA supplementation, combined with dietary and lifestyle intervention, on gut microbiota and biochemical parameters. Methods: Twelve Caucasian obese children (5 males, 7 females), aged 6-14 years (mean age 10 y), were enrolled. Study protocol was approved by the local Ethics Commitee and registered on ClinicalTrials.gov (identifier: NCT04151758). Blood and stool samples

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补充二十二碳六烯酸对肥胖儿童微生物群的影响:一项初步研究。(DAMOCLE研究)。

肥胖症是一种与代谢改变相关的炎症。最近的研究表明，肠道微生物群在其发病机制中起着重要作用，因为与正常体重相比，肥胖与细菌多样性降低和厚壁菌门/拟杆菌门比率(F/R比率)升高有关。这种改变可以影响代谢物的产生(主要是短链脂肪酸)，从而影响炎症标志物的调节和胰岛素的分泌。目的和研究:确定4个月500 mg/d DHA补充，结合饮食和生活方式干预，对肠道微生物群和生化参数的影响。方法:选取12例6 ~ 14岁的高加索肥胖儿童(男5例，女7例)，平均年龄10岁。研究方案已获得当地伦理委员会批准，并在ClinicalTrials.gov上注册(标识符:NCT04151758)。血液和粪便样本

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Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease

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