Low Power Spike Detector for Brain-Silicon Interface using Differential Amplitude Slope Operator

Gerardo Saggese, Efstratios Zacharelos, A. Strollo
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Abstract

High-density implantable microelectrode arrays allow to study in-vivo a wide neuron population with the help thousands of integrated electrodes. Such a high electrodes count generates a large amount of data which poses severe challenges in the design of long-term implantable silicon interfaces that rely on a limited power budget and a narrow transmission bandwidth. In such a scenario, reliable spike detectors are needed, as they allow to transmit only the relevant neural information (the neuron action potential) instead of the whole raw recording. Spike detectors based on energy operators provide a good compromise between detection performance and hardware complexity. However, they require a suitable smoothing filter that affects both area occupation and power dissipation. In this paper, we propose a spike detector based on the cascade of two energy operators, without smoothing, and the use of a new simple adaptative threshold calculation. We show that this technique provides good detection metrics compared to previous approaches, for different SNR levels and with several noise models. The proposed system has been synthesized in TSMC 28 nm CMOS technology showing a per-channel area occupation of 0.0021 m$\text{m}^{2}$ with a power consumption of 0.15 $\mu$W, comparing favorably with the state of art of brain machine silicon interfaces.
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基于差分振幅斜率算子的脑硅界面低功率尖峰检测器
高密度可植入的微电极阵列允许在体内研究广泛的神经元群,帮助成千上万的集成电极。如此高的电极数量产生了大量的数据,这对长期植入式硅接口的设计提出了严峻的挑战,这些接口依赖于有限的功率预算和狭窄的传输带宽。在这种情况下,需要可靠的脉冲检测器,因为它们只允许传输相关的神经信息(神经元动作电位),而不是整个原始记录。基于能量算子的尖峰检测器在检测性能和硬件复杂性之间提供了很好的折衷。然而,它们需要一个合适的平滑滤波器,同时影响面积占用和功耗。在本文中,我们提出了一种基于两个能量算子级联的尖峰检测器,没有平滑,并使用了一种新的简单的自适应阈值计算。我们表明,与以前的方法相比,该技术提供了良好的检测指标,适用于不同的信噪比水平和几种噪声模型。该系统采用台积电28纳米CMOS技术合成,其每通道面积占用为0.0021 m$\text{m}^{2}$,功耗为0.15 $\mu$W,与目前先进的脑机硅接口相比具有优势。
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