MicroRNA in Lymph in Experimental Breast Cancer

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI:10.1109/CSGB.2018.8544812

A. Kabakov, O. Kazakov, A. Poveshchenko, A. Lykov, T. Reiter, D. N. Strunkin, L. F. Gulyaeva, V. Konenkov

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引用次数: 1

Abstract

Breast cancer (BC) is the leading cause of cancer death in women worldwide due to the complicated etiology involving both genetic and environmental factors. Objective: To study the expression levels of miRNAs (-21, -221, -222, -429) in lymph in Wistar female rats in chemically induced breast cancer, resection and chemotherapy of breast cancer. Methods-The histological type of BC, the phenotype of BC cells, the level of mIRNAs expression in lymph was studied. Results-MNU-induced breast cancer in animal has ER-/PG+/Her2/neu- phenotype and therefore has common feature with human luminal A subtype of breast cancer. In the breast cancer group, lymphomas significantly increased the levels of miRNA-21 and miRNA-221 expression compared to the control group. After chemotherapy, the expression levels of miRNA-21 and miRNA-221 were significantly reduced compared to the BC group. In the BC group, the expression levels of miRNA-429 are significantly reduced compared to the control group. After chemotherapy, the expression of miRNA-429 is significantly increased in comparison with the BC group. Conclusion-In lymph miRNA-21 and miRNA-221 are diagnostic-relevant tumor markers. MicroRNA-429 is diagnostic-relevant marker of the chemotherapy effectiveness.

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实验性乳腺癌淋巴中的MicroRNA

乳腺癌(BC)是世界范围内女性癌症死亡的主要原因，由于其复杂的病因涉及遗传和环境因素。目的:研究Wistar雌性大鼠在化学诱导乳腺癌、乳腺癌切除及化疗过程中淋巴组织中mirna(-21、-221、-222、-429)的表达水平。方法观察BC的组织学分型、细胞表型、淋巴组织中mIRNAs的表达水平。结果:mnu诱导的动物乳腺癌具有ER-/PG+/Her2/ new表型，与人腔A亚型乳腺癌具有共同特征。在乳腺癌组中，与对照组相比，淋巴瘤显著增加了miRNA-21和miRNA-221的表达水平。化疗后，与BC组相比，miRNA-21和miRNA-221的表达水平明显降低。在BC组中，miRNA-429的表达水平与对照组相比显著降低。化疗后，miRNA-429的表达较BC组明显升高。结论:在淋巴中，miRNA-21和miRNA-221是诊断相关的肿瘤标志物。MicroRNA-429是化疗疗效的诊断相关标志物。

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$2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB)$