Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544809
O. Shumkov, M. Smagin, V. Nimaev, A. Sadovskiĭ
Radiofrequency ablation of the superficial venous systems has become one of the mainstays of minimally invasive approaches to varicose veins and chronic venous insufficiency. These procedures have high rates of success with scarce complications. Radiofrequency obliteration of the subcutaneous veins can be a method of choice in patients with obesity.
{"title":"Radiofrequency ablation of varicose veins in obese patients","authors":"O. Shumkov, M. Smagin, V. Nimaev, A. Sadovskiĭ","doi":"10.1109/CSGB.2018.8544809","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544809","url":null,"abstract":"Radiofrequency ablation of the superficial venous systems has become one of the mainstays of minimally invasive approaches to varicose veins and chronic venous insufficiency. These procedures have high rates of success with scarce complications. Radiofrequency obliteration of the subcutaneous veins can be a method of choice in patients with obesity.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122322710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544772
N. Bgatova, Olga Solovjeva, S. Shatskaya, Iuliia S. Taskaeva, V. Isupov, V. Makarova, A. Dotsenko, Yuriy I. Borodin, Eugene Zavyalov
Depression is commonly comorbid in cancer patients and has detrimental effects on disease progression. Evidence suggests that biological mechanisms may induce the onset of cancer-induced depression. The neuroprotective effects of lithium carbonate in conditions of peripheral tumor growth were analyzed. It was shown that peripheral tumor growth affects on the behavior and ultrastructural organization of prefrontal cortex neurons of the experimental animals. The phenomena of neurons cytoplasm swelling, decreasing of volume density of transport vesicles, autophagosomes, late endosomes and free polysomal ribosomes were noted. Oral administration of lithium carbonate leads to the accumulation of lithium in the structures of the brain, an increases the motional activity of animals and activates neuron systems of vesicular traffic and degradation.
{"title":"NEUROPROTECTIVE EFFECTS OF LITHIUM CARBONATE IN CONDITIONS OF TUMOR GROWTH","authors":"N. Bgatova, Olga Solovjeva, S. Shatskaya, Iuliia S. Taskaeva, V. Isupov, V. Makarova, A. Dotsenko, Yuriy I. Borodin, Eugene Zavyalov","doi":"10.1109/CSGB.2018.8544772","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544772","url":null,"abstract":"Depression is commonly comorbid in cancer patients and has detrimental effects on disease progression. Evidence suggests that biological mechanisms may induce the onset of cancer-induced depression. The neuroprotective effects of lithium carbonate in conditions of peripheral tumor growth were analyzed. It was shown that peripheral tumor growth affects on the behavior and ultrastructural organization of prefrontal cortex neurons of the experimental animals. The phenomena of neurons cytoplasm swelling, decreasing of volume density of transport vesicles, autophagosomes, late endosomes and free polysomal ribosomes were noted. Oral administration of lithium carbonate leads to the accumulation of lithium in the structures of the brain, an increases the motional activity of animals and activates neuron systems of vesicular traffic and degradation.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122499393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544908
A. Letyagin, A. Shurlygina, IB Belan, M. Robinson, V. Trufakin, Yuriy I. Borodin
The combination of somatic and visceral lymph nodes plays a leading role in the formation of the daily internal temporal order of the lymphoid system. Using the apparatus of mathematical modeling of the lymphocytes movement provides an integrative picture of the temporal organization of cellular and tissue kinetics of lymph nodes of different locations. Regional differences in the formation of daily biorhythms of cellular composition, activity of drainage systems, lymphoid structures and microenvironment of lymph nodes in connection with the rhythms of nutrition, motor activity, sleep-wakefulness are characterized. The influence of the genetic factor on the spatial-temporal organization of dynamic processes in the lymph nodes of different localization was revealed. The power and directivity of the fluxes of cellular movements, as well as the fluid balance cause different strength of the immune response of different phases of the daily cycle.
{"title":"Simulation of circadian temporal organization of the lymph node system using the automated expert program SMLN","authors":"A. Letyagin, A. Shurlygina, IB Belan, M. Robinson, V. Trufakin, Yuriy I. Borodin","doi":"10.1109/CSGB.2018.8544908","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544908","url":null,"abstract":"The combination of somatic and visceral lymph nodes plays a leading role in the formation of the daily internal temporal order of the lymphoid system. Using the apparatus of mathematical modeling of the lymphocytes movement provides an integrative picture of the temporal organization of cellular and tissue kinetics of lymph nodes of different locations. Regional differences in the formation of daily biorhythms of cellular composition, activity of drainage systems, lymphoid structures and microenvironment of lymph nodes in connection with the rhythms of nutrition, motor activity, sleep-wakefulness are characterized. The influence of the genetic factor on the spatial-temporal organization of dynamic processes in the lymph nodes of different localization was revealed. The power and directivity of the fluxes of cellular movements, as well as the fluid balance cause different strength of the immune response of different phases of the daily cycle.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129797314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544837
A. Eremeev, A. Spirov
The field of evolutionary algorithms (EAs) emerged in the area of computer science due to transfer of ideas from biology and developed independently for several decades, enriched with techniques from probability theory, complexity theory and optimization methods. Our aim is to consider how some recent results form EA theory may be transferred back into biology. It has been noted that the EAs optimizing Royal Road fitness functions may be considered as models of evolutionary search for the gene promoter sequences from scratch. Here we consider the design of synthetic promoters from the EAs methodology viewpoint. This problem asks for a tight cluster of supposedly unknown motifs from the initial random (or partially random) set of DNA sequences using SELEX approaches. We apply the upper bounds on the expected hitting time of a target area of genotypic space, the EA runtime, in order to upper-bound the expected time to finding a sufficiently fit series of motifs (e.g. binding sites for transcription factors) in a SELEX procedure. On the other hand, using the EA theory we propose an upper bound on expected proportion of the DNA sequences with sufficiently high fitness at a given iteration of a SELEX procedure. Both approaches are evaluated in computational experiment, using a Royal Road fitness function as a model of the SELEX procedure for regulatory FIS factor binding site. Our results suggest that some theoretically provable bounds for EA performance may be used, at least in principle, for a-priory estimation of efficiency of SELEX-based approaches.
{"title":"Estimates from Evolutionary Algorithms Theory Applied to Gene Design","authors":"A. Eremeev, A. Spirov","doi":"10.1109/CSGB.2018.8544837","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544837","url":null,"abstract":"The field of evolutionary algorithms (EAs) emerged in the area of computer science due to transfer of ideas from biology and developed independently for several decades, enriched with techniques from probability theory, complexity theory and optimization methods. Our aim is to consider how some recent results form EA theory may be transferred back into biology. It has been noted that the EAs optimizing Royal Road fitness functions may be considered as models of evolutionary search for the gene promoter sequences from scratch. Here we consider the design of synthetic promoters from the EAs methodology viewpoint. This problem asks for a tight cluster of supposedly unknown motifs from the initial random (or partially random) set of DNA sequences using SELEX approaches. We apply the upper bounds on the expected hitting time of a target area of genotypic space, the EA runtime, in order to upper-bound the expected time to finding a sufficiently fit series of motifs (e.g. binding sites for transcription factors) in a SELEX procedure. On the other hand, using the EA theory we propose an upper bound on expected proportion of the DNA sequences with sufficiently high fitness at a given iteration of a SELEX procedure. Both approaches are evaluated in computational experiment, using a Royal Road fitness function as a model of the SELEX procedure for regulatory FIS factor binding site. Our results suggest that some theoretically provable bounds for EA performance may be used, at least in principle, for a-priory estimation of efficiency of SELEX-based approaches.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126789712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544784
R. Khapaev, V. Nimaev, O. Shumkov, M. Soluyanov, M. Smagin
A new calculated index is proposed for estimating the volume of extracellular fluid in the soft tissues of the extremities: impedance fluid index (IFI). This indicator, calculated when performing bioempedance measurements of tissues, can be used to assess the severity and nature of the edema of tissues of any etiology. The use of the index for performing low-frequency phase-selective impedanceometry in patients with secondary (postmastectomic) lymphedema of the upper limb is described. The high informative value of the indicator was demonstrated, both in the initial diagnosis and in evaluating the effectiveness of the treatment.
{"title":"New Indicator For Edema Evaluation","authors":"R. Khapaev, V. Nimaev, O. Shumkov, M. Soluyanov, M. Smagin","doi":"10.1109/CSGB.2018.8544784","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544784","url":null,"abstract":"A new calculated index is proposed for estimating the volume of extracellular fluid in the soft tissues of the extremities: impedance fluid index (IFI). This indicator, calculated when performing bioempedance measurements of tissues, can be used to assess the severity and nature of the edema of tissues of any etiology. The use of the index for performing low-frequency phase-selective impedanceometry in patients with secondary (postmastectomic) lymphedema of the upper limb is described. The high informative value of the indicator was demonstrated, both in the initial diagnosis and in evaluating the effectiveness of the treatment.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121718892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/csgb.2018.8544781
{"title":"[Copyright notice]","authors":"","doi":"10.1109/csgb.2018.8544781","DOIUrl":"https://doi.org/10.1109/csgb.2018.8544781","url":null,"abstract":"","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121763850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/csgb.2018.8544751
M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, A. Akimova, O. Poveshchenko, A. Lykov, M. Surovtseva, A. V. Evsyukov, A. Yezhov, A. Zobnin
Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. Thirty four women with 2nd or 3rd Kellgren-radiologic stage OA had been divided into 3 groups. All ones were treated by hyaluronic acid intra-articular injection. Fifteen patients (1st group) hadn’t got any additional treatment. AS was carried out for 6 peoples (2nd group). For 13 patients (3rd group) PRP intra-articular injections were used in common with medical AS. The growth of cartilage in the region of the upper pole of the patella was found in the 1st group after 3 months of treatment: mean values 1.84 vs. 2.39, p = 0.015. Positive dynamic was also detected at 3 and 6 months in the second (the mean values were 2.08 vs. 2.45 and 2.42, p=0.049) and third groups of patients (2.3 vs. 2.8 and 2.35, p=0.02). The cartilage thickness in the medial condyle of the tibia had increased at 3 and 6 months in the 2nd (the mean values were 1.61 vs. 2.11 and 1.98, p = 0.001) and 3rd group (1.66 vs. 2.01 and 1.89, p = 0.019). A change of the cartilage thickness in the lateral condyle of the tibia was not statistically significant in the all groups of patients. The pain level, stiffness, restriction decreased according to the questionnaire (WOMAC, Leken index) in all groups of patients. The clinical effectiveness of intra-articularly hyaluronic acid therapy and surgical methods of OA-treatment (medical AS) have been confirmed by ultrasound visualization and questionnaires.
膝骨关节炎(OA)引起严重的疼痛，身体功能障碍和生活质量受损。目前还没有治愈膝关节炎的方法，对于一些人来说，随着时间的推移，这种疾病可能会出现进行性症状和结构恶化。富血小板血浆(PRP)是一种治疗药物，旨在解决导致OA发病的潜在生物学过程。34例2、3期骨性关节炎患者分为3组。均采用透明质酸关节内注射治疗。15例患者(第一组)未接受任何额外治疗。6人(第二组)行AS。13例患者(第三组)关节内注射PRP与医用AS共用。治疗3个月后，第一组髌骨上极区软骨生长:平均值1.84 vs. 2.39, p = 0.015。第二组患者在第3、6个月时(平均值分别为2.08 vs. 2.45和2.42,p=0.049)和第三组患者(平均值分别为2.3 vs. 2.8和2.35,p=0.02)也出现阳性动态。第2组胫骨内侧髁软骨厚度分别在第3、6个月和第3组(分别为1.61、2.11、1.98,p = 0.001)和第3组(分别为1.66、2.01、1.89,p = 0.019)增加。两组患者胫骨外侧髁软骨厚度变化无统计学意义。根据调查问卷(WOMAC、Leken指数)，各组患者的疼痛程度、僵硬程度、受限程度均有所下降。通过超声显像和问卷调查证实了关节内透明质酸治疗和oa治疗(医学AS)的手术方法的临床疗效。
{"title":"Regenerative technologies in the treatment of knee osteoarthritis","authors":"M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, A. Akimova, O. Poveshchenko, A. Lykov, M. Surovtseva, A. V. Evsyukov, A. Yezhov, A. Zobnin","doi":"10.1109/csgb.2018.8544751","DOIUrl":"https://doi.org/10.1109/csgb.2018.8544751","url":null,"abstract":"Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. Thirty four women with 2nd or 3rd Kellgren-radiologic stage OA had been divided into 3 groups. All ones were treated by hyaluronic acid intra-articular injection. Fifteen patients (1st group) hadn’t got any additional treatment. AS was carried out for 6 peoples (2nd group). For 13 patients (3rd group) PRP intra-articular injections were used in common with medical AS. The growth of cartilage in the region of the upper pole of the patella was found in the 1st group after 3 months of treatment: mean values 1.84 vs. 2.39, p = 0.015. Positive dynamic was also detected at 3 and 6 months in the second (the mean values were 2.08 vs. 2.45 and 2.42, p=0.049) and third groups of patients (2.3 vs. 2.8 and 2.35, p=0.02). The cartilage thickness in the medial condyle of the tibia had increased at 3 and 6 months in the 2nd (the mean values were 1.61 vs. 2.11 and 1.98, p = 0.001) and 3rd group (1.66 vs. 2.01 and 1.89, p = 0.019). A change of the cartilage thickness in the lateral condyle of the tibia was not statistically significant in the all groups of patients. The pain level, stiffness, restriction decreased according to the questionnaire (WOMAC, Leken index) in all groups of patients. The clinical effectiveness of intra-articularly hyaluronic acid therapy and surgical methods of OA-treatment (medical AS) have been confirmed by ultrasound visualization and questionnaires.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115089254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544783
A. Letyagin
Since the methods of clinical diagnostics are becoming more complicated, their implementation takes place within the framework of modeling. In the last century, this was implemented on the basis of analog electronics, now - based on digital technologies in the form of mathematical and / or logical models.
{"title":"Big data and modeling in clinical diagnostics","authors":"A. Letyagin","doi":"10.1109/CSGB.2018.8544783","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544783","url":null,"abstract":"Since the methods of clinical diagnostics are becoming more complicated, their implementation takes place within the framework of modeling. In the last century, this was implemented on the basis of analog electronics, now - based on digital technologies in the form of mathematical and / or logical models.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123773518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544787
D. B. Usmonov, O. Saik, V. Nimaev
Primary leg lymphedema is the wide spread disease of lymphatic system and has different forms of clinical appearances. Analysis of clinical forms of leg lymphedema in connection with creation of associative gene network can help to identify some new candidate genes of lymphedema,
{"title":"Analysis of clinical forms of leg lymphedema. Single-center experience","authors":"D. B. Usmonov, O. Saik, V. Nimaev","doi":"10.1109/CSGB.2018.8544787","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544787","url":null,"abstract":"Primary leg lymphedema is the wide spread disease of lymphatic system and has different forms of clinical appearances. Analysis of clinical forms of leg lymphedema in connection with creation of associative gene network can help to identify some new candidate genes of lymphedema,","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117207699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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