{"title":"Dielectrophoresis, cell culture, and Electrical Impedance Spectroscopy Applied to Adherent Cells in a Single Biochip","authors":"E. Lennon, S. Ostrovidov, V. Senez, T. Fujii","doi":"10.1109/MMB.2006.251518","DOIUrl":null,"url":null,"abstract":"In this work, we present a device that performs the 4 following functions: fluidic handling of biological cells suspension, electrical manipulation of cells by dielectrophoresis, cell culture and electrical impedance detection of adherent cells. Microfabrication process of the device, a hybrid glass/metal/PDMS structure, is detailed. Dielectrophoretic manipulation, culture and cell detection have been performed in a single device using human hepatocellular liver carcinoma cell. Results of broadband (10-107 Hz) electrical impedance spectroscopy (EIS) measurement performed on human cancerous cells are exposed","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2006 International Conference on Microtechnologies in Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MMB.2006.251518","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
In this work, we present a device that performs the 4 following functions: fluidic handling of biological cells suspension, electrical manipulation of cells by dielectrophoresis, cell culture and electrical impedance detection of adherent cells. Microfabrication process of the device, a hybrid glass/metal/PDMS structure, is detailed. Dielectrophoretic manipulation, culture and cell detection have been performed in a single device using human hepatocellular liver carcinoma cell. Results of broadband (10-107 Hz) electrical impedance spectroscopy (EIS) measurement performed on human cancerous cells are exposed
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