Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach

Middle East Research Journal of Pharmaceutical Sciences Pub Date : 2021-12-27 DOI:10.36348/merjps.2022.v02i01.002

Shayara Bano, J. Malik

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Abstract

Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.

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绿原酸是一种有效的抗炎剂:硅分子对接方法

摘要:绿原酸(5- o -咖啡酰奎宁酸)是羟基肉桂酸家族的酚类化合物。这种多酚具有许多增强健康的特性，其中大多数与代谢综合征的治疗有关，包括抗氧化、抗炎、降脂、抗糖尿病和降压作用。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。防止食物中其他生物活性化合物降解的保护特性和益生元活性。方法:采用AutoDock技术将COX2、NF-κB诱导激酶(NIK)和磷脂酶a2 (PLA2)与绿原酸进行分子对接。结果:分子对接结果显示绿原酸具有较高的对接评分。对接分数分别为-6.71、-6.31和-4.43 kcal mol-1。

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Middle East Research Journal of Pharmaceutical Sciences

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