Solid lipid nanoparticles with stearic acid stabilized with yttrium stearate

A. Shirokikh, M. Koroleva, E. Yurtov
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Abstract

In this work, we studied the effect of yttrium stearate on the physicochemical properties of dispersions of solid lipid nanoparticles composed of stearic acid stabilized with nonionic surfactants (Tween 60, Span 60). The results showed that an increase in the concentration of yttrium stearate leads to increasing kinetic stability and decreasing the average size of the aggregates. Along with this, the average size of single particles remains practically unchanged and amounts to 35±5 nm.
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固体脂质纳米颗粒与硬脂酸稳定与硬脂酸钇
在这项工作中,我们研究了硬脂酸钇对由非离子表面活性剂稳定的硬脂酸组成的固体脂质纳米颗粒分散体的物理化学性质的影响(Tween 60, Span 60)。结果表明,随着硬脂酸钇浓度的增加,聚合体的动力学稳定性提高,平均粒径减小。与此同时,单个颗粒的平均尺寸几乎保持不变,为35±5 nm。
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