Optimized structured treatment interruption for HIV therapy and its performance analysis on controllability

2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601) Pub Date : 2006-02-21 DOI:10.1109/CDC.2004.1428828

Ji-hyun Ko, Wonhee Kim, C. Chung

引用次数: 30

Abstract

This paper presents dynamic programming therapy to reduce medication and establish long-term immune response against HIV-infection. Understanding HIV-relaled immune system control enables better HIV therapy without using full-treatments. Discrete regimen and continuous regimen characteristics are compared. Controllability of HIV-related immune system is analyzed for better understanding of optimal control in HIV therapy. Using optimal control provides more effective therapy than the full treatment without interruption in terms of controllability analysis. Case studies indicated the proposed therapy induces long-term non-progression while preserving high CD4 T-helper cell count and low virus load in HIV-infected patients.

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HIV治疗的优化结构化治疗中断及其可控性绩效分析

本文提出了动态规划疗法，以减少药物和建立长期的免疫应答hiv感染。了解HIV相关的免疫系统控制可以在不使用全面治疗的情况下更好地治疗HIV。比较了离散方案和连续方案的特性。分析HIV相关免疫系统的可控性，以便更好地理解HIV治疗中的最优控制。在可控性分析方面，使用最优控制比不间断的完全治疗提供更有效的治疗。病例研究表明，拟议的治疗诱导长期无进展，同时在hiv感染患者中保持高CD4 t辅助细胞计数和低病毒载量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601)

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