Perbandingan Kadar 25-(OH)-Vitamin D3 pada Serum Kelompok Mioma Uteri dan Non-Mioma Uteri

Abstract

Abstrak Tujuan : Penelitian ini bertujuan untuk membandingkan perbedaan kadar 25-hidroksi-vitamin D3 pada serum kelompok mioma uteri dan non-mioma uteri. Metode : Penelitian ini merupakan penelitian analitik observasional dengan rancangan komparatif cross sectional. Subjek penelitian adalah wanita usia reproduksi yang menjalani prosedur laparatomi/laparaskopi yang memenuhi kriteria inklusi penelitian (n=42). Subjek penelitian dibagi menjadi dua kelompok, yakni kelompok mioma uteri (n=21) dan non-mioma uteri (n=21). Pada kedua kelompok dilakukan pemeriksaan kadar serum 25-hidroksi-vitamin D3 kemudian diperiksa dengan metode Electro-chemiluminescence Immunoassay (ECLIA). Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Juni−Agustus 2017. Hasil : Hasil penelitian menunjukkan kadar 25-hidroksi-vitamin D3 rata-rata pada kelompok mioma uteri adalah 6,70 (3,29) ng/ml, sementara pada kelompok non-mioma uteri 10,34 (2,79) ng/ml. Perbedaan kadar rata-rata 25-hidroksi-vitamin D3 pada kedua kelompok tersebut bermakna dengan nilai p<0,001. Namun, tidak didapatkan korelasi antara kadar 25-hidroksi-vitamin D3 dengan berat massa mioma uteri. Kesimpulan : Kadar 25-hidroksi-vitamin D3 pada kelompok mioma uteri lebih rendah dibandingkan dengan kelompok non-mioma uteri. Key words : Mioma uteri, vitamin D,  25-hidroksi-vitamin D3 Abstract Objective : The aim of this study was to determine if there is any significant difference between serum levels of 25-hydroxy-vitamin D3 of uterine fibroid group and non-uterine fibroid group. Method : This was an observational analytic study with comparative cross-sectional method. Subjects were women in reproductive age who underwent laparotomy / laparoscopy procedures who met the study criteria (n=42). The subjects were divided into two groups, uterine fibroid group (n=21) and non-uterine fibroid (n=21). Measurement of serum 25-hydroxy-vitamin D3 was performed using Electro-chemiluminescence Immunoassay (ECLIA) method. The study was conducted at Dr. Hasan Sadikin hospital in June−August 2017. Result : The results showed the mean level 25-hydroxy-vitamin D3 on uterine fibroid group was 6.70 (3.29) ng / ml and non-uterine fibroid group 10.34 (2.79) ng/ml. There was significant difference between serum level of 25-hydroxy-vitamin D3 in uterine fibroid group and non-uterine fibroid with p value <0.001. But, there was no correlation between serum level of 25-hydroxy-vitamin D3 content and the weight of uterine fibroid mass. Conclusions : Serum level of 25-hydroxy-vitamin D3 is lower in uterine fibroid group than non-uterine fibroid group. Key words : Uterine fibroid, vitamin D, 25-hydroxy-vitamin D3