Evaluation of the Liver Function and Haematological Parameters of Wistar Rats Fed with Casein Protein

Abstract

Casein is the major protein found in bovine milk. Universally used in human nutrition for all ages and in the dairy industry, milk is regarded as whole food which provides high quality protein and indispensable micronutrients such as vitamins and minerals. The evaluation of the liver function test and haematological parameters of rats fed with casein protein was carried out. Graded levels of casein protein were incorporated into the diets of experimental rats at 20%, 30% and 50% concentrations. At the end of twenty-eight days, blood samples were collected and analyzed for liver function and haematological parameters. Statistically significant increases were observed in lactate dehydrogenase, gamma glutamyl transferase, alanine transaminase, aspartate transaminase and alkaline phosphatase activity levels when compared with the control. Also the granulocytes and platelets counts were significantly reduced. Consistent consumption of high concentrations of casein proteins may elevate liver enzyme activities and attenuate some haematological parameters.