Joint use of Ca – Modified Double-Strained RNA as an Immunostimulator with a Vaccine for the Prevention of Food andMouth Disease (FMD)

Abstract

The purpose of this work is to study the effect of combined use of the immunostimulant preparation which is double-stranded Ca-modified RNA with inactivated FMD vaccine for cattle against A, O and Asia-1 subtypes of FMD. Preparation have been received from sodium nucleinate or allocated from a killer yeast of Saccharomices cerewisiae. The modification of Ca ions assayed by the addition of sterile solution of calcium chloride. Based on received data it can be concluded that the using of immunomodulator in cattle induces more early and high immune response. The FMD vaccine intramuscular administration together with the preparation provides high enough of an immune response and high titer of antibody maintained for a period of 90 days (time of observation).