Circadian Rhythm and Polygenic Risk Scores

Abstract

Genome-wide association study (GWAS) have led to paradigm shift in the study of psychiatric illnesses. However, GWAS has certain limitations. Thus, investigators have invented the concept of polygenic risk using GWAS. The current study aimed to review the papers on the association between polygenic risk score (PRS) and circadian rhythm. Circadian preferences are indicative of endogenous circadian rhythms. Some studies have revealed that the PRS for circadian preferences is associated with sleep timing, median sleep time, and the risk of bipolar disorder. Moreover, another study revealed that the PRS for diabetes, Alzheimer’s disease, and mood disorders was associated with sleep patterns, wakefulness after sleep onset, and circadian rhythm. In conclusion, the PRS is an anticipated biomarker for predicting diagnosis, treatment response, and clinical outcomes. Thus, PRS will play many roles in personalized medicine soon.