Effect Of Cholecalciferol As An Antioxidant On Hypercholesterolemic Rats

Abstract

: In recent years, much evidence showed that vitamin D 3 deficiency could be related to several chronic diseases such as diabetes and cardiovascular disease. So, the goal of the study is to assess the effect of cholecalciferol on hypercholesterolemic rats at different levels of vitamin D 3 . Methods : Fifty six albino rats were in corporate as follows: G (1) (eight rats) was fed a basal diet, like a negative group. The second main group (48 rats) will be received for 8 weeks (a diet containing 10% sucrose, 0.25%bile salts and 1% cholesterol) to induce hypercholesterolemia in rats. For 8 weeks and divided into six subgroups (8rats each): the first group administrated hypercholesterolemic diet as a positive control group from,( 2 nd : 7 th ) groups administrated on hypercholesterolemic diet and vitamin D 3 with different levels (0.5, 0.1, 1.5, 2, 2.5 mg /kg diet) . Results: The group of hypercholesterolemic recorded a highly remarkable increase in serum CHO,TG,LDL,VLDL,HBA1c , tissue malondialdehyde ( MDA ) and a decrease in serum HDL,Vit D 3 and in tissue SOD and GSH when compared with (-ve)group.But administered with vitamin D 3 at different