Impact of Aflatoxins Exposure on Human Health and its Management Strategies

N. Zahra, Muhammad Hassan Raza, Faheem Hafeez, M. Saeed, S. A. Khan, A. Saeed, K. Shahzad
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Abstract

Aflatoxins are common contaminants in human food supplies that affects the world's developing economies. These are cosmopolitan in distribution and found everywhere in nature and can grow under drought, warm, and humid conditions. The aflatoxins are secondary metabolites and mostly found in feed and food products. These areoncogenic, mutagenic, and immunosuppressive in nature. On the basis of the aflatoxin producing fungi, the aflatoxins are roughly split into two distinct groups: those that penetrate in pre-harvest circumstances and those that are generated in post-harvest conditions. Aflatoxins exposure has great public health impact in economically developing nations and lot of research is taking place to reduce its harmful impacts; as a result, we need to establish preventive strategies that are feasible for these high-risk populations. This review provides in-depth information regarding the presence of aflatoxins, their analysis, and potentially harmful consequences on human health, as well as various detoxification approaches.
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黄曲霉毒素暴露对人体健康的影响及其管理策略
黄曲霉毒素是人类食物供应中常见的污染物,影响着世界上的发展中经济体。它们分布在世界各地,在自然界中随处可见,可以在干旱、温暖和潮湿的条件下生长。黄曲霉毒素是次生代谢产物,主要存在于饲料和食品中。这些物质具有致癌性、诱变性和免疫抑制性。根据产生黄曲霉毒素的真菌,黄曲霉毒素大致分为两类:在收获前环境中渗透的和在收获后条件下产生的。黄曲霉毒素暴露对经济发展中国家的公众健康有重大影响,人们正在进行大量研究以减少其有害影响;因此,我们需要制定对这些高危人群可行的预防战略。本文综述了黄曲霉毒素的存在、分析及其对人体健康的潜在危害,以及各种解毒方法。
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