Identification of Prognostic Markers for LUAD based on Rank Expression of Long non-coding RNA

Abstract

lung adenocarcinoma (LUAD) is the highest incidence of malignant tumors in China, because its early symptoms are not easily ignored by most people, so screening reliable markers is the focus of research. In order to screen stable, cross-platform prognostic lncRNA of LUAD, we combined gene expression profiles and RNAseq data to screen stable lncRNA pairs shared by both platforms and significantly reversed lncRNA pairs in LUAD samples, and then screened the prognostic-related lncRNA from the reversed lncRNA pairs. The stability of the gene pairs obtained from the normal samples was 98.72%. Twenty pairs of survival-related significantly reversed lncRNA gene pairs with 33 lncRNA were found. The results of functional enrichment showed that the functions of these lncRNA pairs were consistent with the known results. Because of its cross-platform and easy detection of independent samples, this result can be better applied to clinical diagnosis and can detect the risk and prognosis of possible LUAD in advance.