{"title":"INFLAMM-AGING: A MECHANISM OF AGING THAT CONTRIBUTES TO THE CHARACTERISTICS OF SKIN INVOLVEMENT IN SYSTEMIC SCLEROSIS","authors":"N. Gokcen","doi":"10.56543/aaeeu.2022.1.1.07","DOIUrl":null,"url":null,"abstract":"Aging is associated with deterioration of the immune function. Two contributory mechanisms are inflamm-aging, which is a chronic, low-grade systemic inflammation, and immunosenescence, an impairment of adaptive immune function that may also contribute to the development of inflamm-aging. This age-related inflammatory event is associated with alteration to the balance of pro-inflammatory and anti-inflammatory cytokines. The effect of inflamm-aging on skin aging in healthy people is accepted; however, its effect on normal skin aging and/or skin characteristics in systemic sclerosis is unknown. The hypothesis presented herein suggests that inflamm-aging may contribute to the evolution of the skin phases in systemic sclerosis, which progress from edematous, fibrotic, and indurative phases to the atrophic phase.","PeriodicalId":437966,"journal":{"name":"Anti-Aging Eastern Europe","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anti-Aging Eastern Europe","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56543/aaeeu.2022.1.1.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Aging is associated with deterioration of the immune function. Two contributory mechanisms are inflamm-aging, which is a chronic, low-grade systemic inflammation, and immunosenescence, an impairment of adaptive immune function that may also contribute to the development of inflamm-aging. This age-related inflammatory event is associated with alteration to the balance of pro-inflammatory and anti-inflammatory cytokines. The effect of inflamm-aging on skin aging in healthy people is accepted; however, its effect on normal skin aging and/or skin characteristics in systemic sclerosis is unknown. The hypothesis presented herein suggests that inflamm-aging may contribute to the evolution of the skin phases in systemic sclerosis, which progress from edematous, fibrotic, and indurative phases to the atrophic phase.
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