Thermosensitive and pH-sensitive Drug Release from Taxifolin-Containing Collagen-Acrylic Hydrogels

Abstract

The variety of skin diseases encourage the creation of new coatings, the search for a suitable wound dressing. Significant success has been achieved with hydrogel dressings containing biologically active compounds for the healing of wounds of varying severity. The aim of this work was to obtain taxifolin-containing hydrogels based on acrylic acid and collagen as the basis for a wound dressing. The gelation time, sorption kinetics based on a pseudo-second order model and a mathematical model, as well as the drug release of the obtained samples based on the Korsmeyer-Peppas, Higuchi, Baker-Lonsdale, Hopfenberg, Weibull models, respectively, with variation of solvent pH and sorption temperature have been studied. Sorption characteristics of polymer hydrogel matrix containing 0.5 wt.% taxifolin reaches the values from 25 to 30 g/g, respectively at the various pH solvent. The release of taxifolin in the buffer solutions with pH=5.8 and pH=7.2 carries out in two stages. The best release of the drug substance is observed for the sample containing taxifolin in an alkaline medium and is described by the Hopfenberg model.