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2022 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES)最新文献

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Development of IoT-Based, Origami-Inspired Wearable Rehabilitation Device for Wrist-Finger Mobility Rehabilitation 基于物联网的折纸式腕指活动康复可穿戴设备的研制
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079609
Y. Z. Chong, C. Tan, S. Chan, Choon-Hian Goh
There are various upper-extremities rehabilitation systems available to cater for various communities-in-need. Majority of these systems have only a single pre-programmed protocol. This paper aims to design and develop an affordable (~MYR 230), light-weight (~250 g) exoskeleton system where the transmission mechanism is based on elements of origami string technique. The features of the system include light-mass; passive movement rehabilitation of the finger (flexion-extension at MCP and PIP joints) and wrist (extension at radiocarpal joint); user-centric rehabilitation protocols; status review of rehabilitation. The system also incorporated sensing systems (flex sensors) to record various biomechanical measurements; control system (ESP32); actuator system (MG995 servo motors) alongside with a mobile application that allows the user to select the rehabilitation protocols, view rehabilitation progress and learn how to fold origami models. It is anticipated that this development will be a platform to further explore on the adaptation of origami techniques in development of rehabilitation devices.
有各种上肢康复系统,以满足不同社区的需要。这些系统中的大多数只有一个单独的预编程协议。本文旨在设计和开发一种价格合理(~MYR 230),重量轻(~250 g)的外骨骼系统,其传动机构基于折纸弦技术的元素。该系统的特点包括:轻质量;手指(MCP和PIP关节的屈伸)和手腕(桡腕关节的伸展)的被动运动康复;以用户为中心的康复协议;康复状况回顾。该系统还集成了传感系统(柔性传感器)来记录各种生物力学测量;控制系统;ESP32;执行器系统(MG995伺服电机)以及一个移动应用程序,允许用户选择康复方案,查看康复进度并学习如何折叠折纸模型。预计这一发展将为进一步探索折纸技术在康复设备开发中的适应性提供一个平台。
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引用次数: 0
IECBES 2022 Cover Page IECBES 2022封面
Pub Date : 2022-12-07 DOI: 10.1109/iecbes54088.2022.10079432
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引用次数: 0
Effects of Data Structure in Convolutional Neural Network for Detection of Asynchronous Breathing in Mechanical Ventilation Treatment 卷积神经网络数据结构在机械通气治疗中异步呼吸检测中的作用
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079652
Christopher Yew Shuen Ang, N. L. Loo, Y. Chiew, C. P. Tan, M. Nor, J. Chase
Asynchronous breathing (AB) in mechanical ventilation (MV) patients is heterogenous, patient-specific, and is associated with adverse patient outcomes. Various machine learning models have been developed for AB detection, however studies regarding the data structures used for model training are scarce. This study investigates the effects of different training data structures and sizes of Convolutional Neural Networks (CNN) to detect AB. Four CNN models were developed using different amounts of data and data structures: one-dimension, line, area, and array. Training datasets consisting of 300, 1,000, 5,000 and 10,000 airway pressure waveforms from MV patients were used for model development. Model sensitivity and specificity were evaluated using an independent set of 3000 waveforms in a 100-iteration Monte-Carlo analysis. The best-performing CNN model was used to determine Asynchrony Index (AI) values in a clinical patient cohort. Monte-Carlo analysis showed that models trained with datasets of 10,000 breathing cycles delivered $gt99$% sensitivity and specificity. Relatively lower sensitivity and specificity of $lt78.8$% and $lt96.7$% respectively were obtained when trained with data quantities of 5000 breaths or less. A CNN trained with 1Dimensional data structure yielded 99.9% sensitivity and 99.6% specificity. It achieved 88.5% average accuracy when validated with an independent clinical data set of 544,319 breaths. Asynchrony breathing detection is ubiquitous and 1-Dimensional data structures provide a resource efficient method for the development of an accurate CNN model.
机械通气(MV)患者的异步呼吸(AB)是异质性的,患者特异性的,并且与不良患者结局相关。已经开发了用于AB检测的各种机器学习模型,但是关于用于模型训练的数据结构的研究很少。本研究探讨了不同训练数据结构和大小对卷积神经网络(CNN)检测AB的影响。使用不同的数据量和数据结构:一维、线、面积和数组,开发了四种卷积神经网络模型。由来自MV患者的300、1,000、5,000和10,000个气道压力波形组成的训练数据集用于模型开发。在100次迭代的蒙特卡罗分析中,使用一组独立的3000个波形来评估模型的灵敏度和特异性。使用表现最好的CNN模型来确定临床患者队列中的异步指数(AI)值。蒙特卡罗分析显示,使用10,000个呼吸周期数据集训练的模型具有$ $ gt99$%的灵敏度和特异性。当数据量为5000次或更少呼吸时,获得的灵敏度和特异性相对较低,分别为$ lt78.8%和$lt96.7$%。用一维数据结构训练的CNN灵敏度为99.9%,特异度为99.6%。当使用独立的临床数据集544,319次呼吸进行验证时,其平均准确率达到88.5%。异步呼吸检测无处不在,一维数据结构为开发准确的CNN模型提供了一种资源高效的方法。
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引用次数: 0
Functional Connectivity Based Classification for Autism Spectrum Disorder Using Spearman’s Rank Correlation 基于功能连接的自闭症谱系障碍的Spearman秩相关分类
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079445
Xin Yang, R. Rimal, Tiffany Rogers
Due to the continuous advances in brain imaging technology, an increasing number of large-scale brain research projects have been derived, such as the ABIDE Initiative. These developments have enabled us to gain an unprecedentedly detailed insight into brain activity by analyzing brain imaging data, which will reshape our understanding of brain activity and uncover biomarkers of brain disease.Over the past decade, the analysis of resting-state functional connectivity has become a trend because brain connectivity provides an effective way to understand how spatially distant brain regions interact and achieve coherent neural functions. One of the most common approaches to analyze functional connectivity is the Pearson correlation. This paper uses a new correlation method to calculate functional connectivity: Spearman’s rank correlation. We apply two conventional machine learning methods to classify autism spectrum disorder (ASD) patients from typically developing (TD) participants based on functional connectivity derived from resting-state functional magnetic resonance imaging (fMRI) data. To verify the feasibility and validity of Spearman’s rank correlation in the classification of autism, we compared the accuracy, sensitivity, and specificity of methods using functional connectivity obtained from Pearson’s correlation and Spearman’s rank correlation. Moreover, feature selection is one of the essential tasks in classification studies. We present an empirical comparison of two feature selection methods: select from model (SFM) and recursive feature elimination (RFE).
由于脑成像技术的不断进步,越来越多的大型脑研究项目被衍生出来,例如“遵守倡议”。这些发展使我们能够通过分析脑成像数据获得对大脑活动前所未有的详细了解,这将重塑我们对大脑活动的理解,并揭示大脑疾病的生物标志物。在过去的十年里,静息状态功能连通性的分析已经成为一种趋势,因为大脑连通性提供了一种有效的方法来了解空间上遥远的大脑区域如何相互作用并实现连贯的神经功能。分析功能连通性的最常用方法之一是Pearson相关性。本文采用了一种新的计算功能连通性的相关方法:Spearman秩相关。我们应用两种传统的机器学习方法,基于静息状态功能磁共振成像(fMRI)数据得出的功能连通性,对自闭症谱系障碍(ASD)患者和典型发育(TD)参与者进行分类。为了验证Spearman等级相关在自闭症分类中的可行性和有效性,我们比较了使用Pearson等级相关和Spearman等级相关得到的功能连通性方法的准确性、敏感性和特异性。特征选择是分类研究的重要内容之一。本文对两种特征选择方法进行了实证比较:模型选择(SFM)和递归特征消除(RFE)。
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引用次数: 0
Strategies on Deep Brain Stimulation Devices for Effective Behavioral Studies in Rodents 用于啮齿类动物有效行为研究的深部脑刺激装置策略
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079260
F. Plocksties, A. Lüttig, Christoph Niemann, Felix Uster, D. Franz, Maria Kober, Maximilian Koschay, S. Perl, A. Richter, R. Köhling, Alexander Storch, D. Timmermann
Deep brain stimulation (DBS) is an essential therapeutic resource for treating movement disorders like dystonia. In order to gain further insight into the underlying disease mechanisms, animal models are used. However, the most critical obstacle for further research is the lack of subcutaneous implantable, miniaturized neurostimulators that can deliver reliable and replicable results. Extracorporeal mounting of neurostimulators on the head or back places a high burden on the animal. Furthermore, the animals frequently tamper with these stimulation setups, leading to high failure rates. In the absence of suitable diagnostic tests, such defects generally escape detection. Therefore, this article presents strategies for a DBS stimulator design intending to increase the scientific merit of behavioral experiments in rodents. In this context, we demonstrate an easy-to-implement, waterproof, biocompatible, and compact encapsulation method suited for full implantation in small rodents. Using this method, we implanted DBS devices subcutaneously in dystonic hamsters that have been successfully tested for up to 17 days.
脑深部电刺激(DBS)是治疗肌张力障碍等运动障碍的重要治疗手段。为了进一步了解潜在的疾病机制,使用了动物模型。然而,进一步研究的最关键障碍是缺乏能够提供可靠和可复制结果的皮下植入式小型化神经刺激器。在头部或背部安装体外神经刺激器会给动物带来沉重的负担。此外,动物经常篡改这些刺激设置,导致高失败率。在没有合适的诊断测试的情况下,这些缺陷通常无法被检测到。因此,本文提出了一种DBS刺激器的设计策略,旨在提高啮齿动物行为实验的科学价值。在这种情况下,我们展示了一种易于实施,防水,生物相容性和紧凑的封装方法,适用于小型啮齿动物的完全植入。使用这种方法,我们将DBS装置植入肌张力障碍仓鼠皮下,这些仓鼠已经成功地进行了长达17天的测试。
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引用次数: 0
A Gesture Controlled System to Train and Guide the Healthcare Workers While Donning and Doffing Personal Protective Equipment 一种手势控制系统,用于培训和指导医护人员穿戴和脱下个人防护装备
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079337
Penglin Qin, Guanghua Xu, Qingqiang Wu, Fan Wei, Zejiang Li, Dakai Zhao
During the COVID-19 outbreak, many healthcare workers (HCWs) have been infected because they failed to comply with the correct process of donning and doffing personal protective equipment (PPE). Based on this, we develop a gesture-controlled system that not only can train HCWs but also can give HCWs real-time guidance during the process of donning and doffing PPE. It can effectively prevent the infection of HCWs. We first use the hand detection algorithm to locate the position of the HCWs, helping them to enter the proper area. Then they can use our gesture recognition algorithm to control the playback of the videos which guides them in donning and doffing PPE. We verify the effectiveness of the system through a series of experiments. The results show the great value of our system in the protection of HCWs.
在2019冠状病毒病暴发期间,许多卫生保健工作者(HCWs)因未能遵守正确的穿戴和脱下个人防护装备(PPE)的流程而受到感染。在此基础上,我们开发了一个手势控制系统,该系统不仅可以训练HCWs,还可以在HCWs穿脱PPE过程中实时指导HCWs。能有效预防卫生保健工作者的感染。我们首先使用手部检测算法来定位HCWs的位置,帮助他们进入合适的区域。然后,他们可以使用我们的手势识别算法来控制视频的播放,指导他们穿上和脱下PPE。通过一系列的实验验证了该系统的有效性。结果表明,该系统在保护重型武器方面具有重要的应用价值。
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引用次数: 0
Exploring the Vibrational and Rotational Temperatures of a DBD Plasma Jet for Wound Healing 探索DBD等离子体射流用于伤口愈合的振动和旋转温度
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079657
Krishnaveni Parvataneni, S. Zaidi
Due to their low gas temperatures, non-thermal, dielectric barrier discharge (DBD) finds frequent applications in wound healing and sterilization. Reactive nitrogen and oxygen species in the plasma play a vital role in this process. The concentration of these radicals is dependent on the plasma’s operating conditions (e.g. applied voltage and gas flow rates). Radicals’ vibrational and rotational temperatures play a vital role in wound healing and are required to find an optimized plasma operating condition for the wound healing process. The current project aims to measure the plasma temperatures (vibrational, rotational, and electronic) for a multi-electrode torch. The emission spectrum for various electrodes of the plasma torch was captured at various operating conditions. For this purpose, an Ocean Optics UV-IR spectrometer in conjunction with SPECAIR was used to estimate the vibrational, rotational, and electronic temperatures of the plasma. For this experiment the multi-electrode plasma torch was operated at various conditions by changing the outer electrodes, gas flow rates (helium 20-40 slpm), and input applied voltages (5kV-10kV and 20-40 kHZ). Experimental results reveal that both plasma vibrational and rotational temperatures $(sim 500mathrm{K}700mathrm{K})$ were dependent on the measuring position from the plasma exit at identical operating conditions. No significant change in electronic temperatures $(sim 2800mathrm{K}$ – 3000K) was observed for all conditions. Detailed results are included in this paper.
由于其气体温度低,非热,介质阻挡放电(DBD)在伤口愈合和灭菌中经常应用。血浆中的活性氮和活性氧在这一过程中起着至关重要的作用。这些自由基的浓度取决于等离子体的操作条件(例如,施加电压和气体流速)。自由基的振动和旋转温度在伤口愈合中起着至关重要的作用,需要为伤口愈合过程找到最佳的等离子体操作条件。目前的项目旨在测量多电极炬的等离子体温度(振动、旋转和电子)。捕获了等离子炬各电极在不同工作条件下的发射光谱。为此,海洋光学UV-IR光谱仪与SPECAIR一起用于估计等离子体的振动、旋转和电子温度。本实验通过改变外电极、气体流速(氦20-40 slpm)和输入电压(5kV-10kV和20-40 kHZ),在不同条件下操作多电极等离子炬。实验结果表明,在相同的操作条件下,等离子体的振动和旋转温度$(sim 500mathrm{K}700mathrm{K})$与等离子体出口的测量位置有关。在所有条件下均未观察到电子温度$(sim 2800 mathm {K}$ - 3000K)的显著变化。本文给出了详细的结果。
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引用次数: 0
NFNets-CNN for Classification of COVID-19 from CT Scan Images NFNets-CNN从CT扫描图像中分类COVID-19
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079453
M. S. Abdullah, A. Radzol, M. Marzuki, K. Y. Lee, S. A. Ahmad
Coronavirus disease (COVID-19) is an infectious disease caused by the coronavirus was first found in Wuhan, China in December 2019. It has infected more than 300 million people with more than 5 million of death cases. Until now, the virus is still evolving producing new variants of concern contributes to the increase the infection rate around the world. Thus, various diagnostic procedures are in need to help physicians in diagnosis disease certainly and rapidly. In this study, deep learning approach is used to classify normal and COVID-19 cases from CT scan images. Normalizer Free CNN network (NFNets) model is implemented on the images. Statistical measures such as accuracy, precision, sensitivity (also known as recall) are used to evaluate the performance of the model against the previous studies. Loss of 0.0842, accuracy of 0.7227, precision of 0.9751 and recall of 0.9727 are achieved. Thus, further optimization on the NFNets learning algorithm is required to improve the classification performanceClinical Relevance–Implementation of deep learning technique to automate diagnosis of diseases such as COVID-19 cases from CT scan images will simplify the clinical flow towards providing reliable intelligent aids for patient care.
冠状病毒病(COVID-19)是一种由冠状病毒引起的传染病,于2019年12月在中国武汉首次发现。它已经感染了3亿多人,死亡病例超过500万。到目前为止,该病毒仍在进化,产生令人担忧的新变种,导致世界各地的感染率上升。因此,需要各种诊断程序来帮助医生准确、快速地诊断疾病。本研究采用深度学习方法从CT扫描图像中对正常病例和COVID-19病例进行分类。在图像上实现了Normalizer Free CNN网络(NFNets)模型。统计指标,如准确性,精密度,灵敏度(也称为召回)被用来评估模型的性能与以前的研究。损失为0.0842,准确率为0.7227,精密度为0.9751,召回率为0.9727。因此,需要对NFNets学习算法进行进一步优化,以提高分类性能。临床相关性——利用深度学习技术从CT扫描图像中自动诊断COVID-19等疾病,将简化临床流程,为患者护理提供可靠的智能辅助。
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引用次数: 0
IECBES 2022 Proceeding - Table of Contents IECBES 2022进程-目录表
Pub Date : 2022-12-07 DOI: 10.1109/iecbes54088.2022.10079484
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引用次数: 0
Segmenting Brain Tumor with an Improved U-Net Architecture 基于改进U-Net结构的脑肿瘤分割
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079331
Der Sheng Tan, Wei Qiang Tam, H. Nisar, K. Yeap
To aid in the clinical diagnosis of brain tumors, magnetic resonance imaging (MRI) is frequently used. The amount of time it takes to manually segment MRI images depends on the radiologist’s level of expertise. In this paper, a novel U-Net architecture for segmenting images of brain tumors is proposed. We have evaluated BraTS 2020 dataset with an improved U-Net structure with a dropout layer inserted between the encoder and decoder to reduce overfitting. By comparing with other U-Net architectures, our method has shown a promising result with dice coefficients 70.40%, 69.08% and 73.03%, for whole tumor (WT), tumor core (TC) and enhanced tumor (ET).
为了帮助临床诊断脑肿瘤,磁共振成像(MRI)经常被使用。手动分割MRI图像所需的时间取决于放射科医生的专业水平。本文提出了一种新的用于脑肿瘤图像分割的U-Net结构。我们使用改进的U-Net结构对BraTS 2020数据集进行了评估,该结构在编码器和解码器之间插入了dropout层,以减少过拟合。通过与其他U-Net架构的比较,我们的方法在全肿瘤(WT)、肿瘤核心(TC)和增强肿瘤(ET)上的骰子系数分别为70.40%、69.08%和73.03%。
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引用次数: 0
期刊
2022 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES)
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